Jolivet-Gougeon Anne, Bonnaure-Mallet Martine
Drug Discov Today Technol. 2014 Mar;11:49-56. doi: 10.1016/j.ddtec.2014.02.003.
Inside the biofilm, antimicrobial agents must overcome high cell density, an increased number of resistant mutants, substance delivery, molecular exchanges, such as high levels of beta-lactamases or inducers of efflux pump expression, and specific adaptive cells, so-called persisters. The environment within the biofilm modulates the response to antibiotics, especially when the SOS response or DNA repair systems are involved. Exposure to subinhibitory concentrations of antibiotics can enhance biofilm formation and mutagenesis. Thus, a global response to cell stress seems to be responsible for antibiotic-induced biofilm formation.
在生物膜内部，抗菌剂必须克服高细胞密度、耐药突变体数量增加、物质传递、分子交换（如高水平的β-内酰胺酶或外排泵表达诱导剂）以及特定的适应性细胞（即所谓的持留菌）。生物膜内的环境会调节对抗生素的反应，尤其是当涉及SOS反应或DNA修复系统时。暴露于亚抑制浓度的抗生素可增强生物膜形成和诱变作用。因此，细胞应激的整体反应似乎是抗生素诱导生物膜形成的原因。
