Yao Xiuzhong, Kuang Tiantao, Wu Li, Feng Hao, Liu Hao, Cheng Weizhong, Rao Shengxiang, Wang He, Zeng Mengsu
Department of Radiology, Zhongshan Hospital of Fudan University, No. 138, Fenglin Road, Xuhui District, Shanghai 200032, China; Department of Medical Image, Shanghai Medical College of Fudan University, Shanghai Institute of Medical Imaging, No. 138, Fenglin Road, Xuhui District, Shanghai 200032, China.
Department of General Surgery, Zhongshan Hospital of Fudan University, No. 138, Fenglin Road, Xuhui District, Shanghai 200032, China.
Magn Reson Imaging. 2014 Sep;32(7):875-9. doi: 10.1016/j.mri.2014.04.011. Epub 2014 Apr 24.
To investigate and optimize diffusion-weighted imaging (DWI) acquisitions for pancreatic cancer at 3.0T.
Forty-five patients with pancreatic cancer were examined by four DWI acquisitions with b values=0 and 600s/mm(2) at 3.0T, including breath-holding DWI (BH-DWI), respiratory-triggered DWI (TRIG-DWI), respiratory-triggered DWI with inversion-recovery technique (TRIGIR-DWI), and free-breathing DWI with inversion-recovery technique (FBIR-DWI). Artifacts, contrast ratio (CR), contrast-to-noise ratio (CNR) and apparent diffusion coefficient (ADC) of pancreatic cancer were statistically compared among DWI acquisitions.
TRIGIR-DWI displayed the lowest artifacts and highest CR compared to other DWI acquisitions. CNRs of pancreatic cancer in TRIG-DWI and TRIGIR-DWI were statistically higher than that in FBIR-DWI and BH-DWI. Different ADCs between pancreatic cancer and noncancerous pancreatic tissues were noticed by a paired-samples T test in TRIG-DWI (p=0.017), TRIGIR-DWI (p=0.00001) and FBIR-DWI (p=0.000041).
TRIGIR-DWI may be the optimal acquisition of DWI for pancreatic cancer at 3.0T.
研究并优化3.0T场强下胰腺癌的扩散加权成像（DWI）采集方法。
45例胰腺癌患者在3.0T场强下采用四种DWI采集方法进行检查，b值分别为0和600s/mm²，包括屏气DWI（BH-DWI）、呼吸触发DWI（TRIG-DWI）、采用反转恢复技术的呼吸触发DWI（TRIGIR-DWI）以及采用反转恢复技术的自由呼吸DWI（FBIR-DWI）。对不同DWI采集方法下胰腺癌的伪影、对比率（CR）、对比噪声比（CNR）及表观扩散系数（ADC）进行统计学比较。
与其他DWI采集方法相比，TRIGIR-DWI的伪影最少，CR最高。TRIG-DWI和TRIGIR-DWI中胰腺癌的CNR在统计学上高于FBIR-DWI和BH-DWI。在TRIG-DWI（p=0.017）、TRIGIR-DWI（p=0.00001）和FBIR-DWI（p=0.000041）中，通过配对样本t检验发现胰腺癌与胰腺非癌组织之间存在不同的ADC值。
TRIGIR-DWI可能是3.0T场强下胰腺癌DWI的最佳采集方法。
