氯氮平诱发一名偏执型精神分裂症患者出现肾小管间质性肾炎。
Clozapine induced tubulointerstitial nephritis in a patient with paranoid schizophrenia.
作者信息
Parekh Ravi, Fattah Zozik, Sahota Dilraj, Colaco Bernie
机构信息
Imperial College, London, UK.
Department of Rheumatology, UCLH, London, UK.
出版信息
BMJ Case Rep. 2014 May 20;2014:bcr2013203502. doi: 10.1136/bcr-2013-203502.
We describe the development of tubulointerstitial nephritis after starting clozapine therapy in a patient with treatment-resistant schizophrenia. A 54-year-old mixed-race patient with a longstanding history of paranoid schizophrenia was started on the antipsychotic clozapine. Two months after starting clozapine he developed fevers, cough and acute renal failure which initially responded to 7 days of prednisolone but recurred after completing the steroid course. Renal biopsy confirmed acute tubulointerstitial nephritis and he was started on a course of steroids with renal recovery in 72 h. Clozapine was later stopped. This case highlights a serious and potential life-threatening complication of an important antipsychotic used in treatment-resistant schizophrenia.
我们描述了一名难治性精神分裂症患者在开始使用氯氮平治疗后发生肾小管间质性肾炎的情况。一名54岁的混血患者，有长期偏执型精神分裂症病史，开始使用抗精神病药物氯氮平治疗。开始使用氯氮平两个月后，他出现发热、咳嗽和急性肾衰竭，最初对泼尼松龙治疗7天有反应，但在类固醇疗程结束后复发。肾活检证实为急性肾小管间质性肾炎，随后他开始接受类固醇疗程治疗，72小时后肾功能恢复。氯氮平后来停用。该病例突出了一种用于难治性精神分裂症的重要抗精神病药物的严重且可能危及生命的并发症。
Zotero 插件