使用小的外取代大环化合物通过铜催化的叠氮化物-炔烃环加成（CuAAC）“点击”活性模板合成功能化[2]轮烷：多小才算太小？
CuAAC "click" active-template synthesis of functionalised [2]rotaxanes using small exo-substituted macrocycles: how small is too small?
作者信息
Noor Asif, Lo Warrick K C, Moratti Stephen C, Crowley James D
机构信息
Department of Chemistry, University of Otago, PO Box 56, Dunedin, New Zealand.
出版信息
Chem Commun (Camb). 2014 Jul 7;50(53):7044-7. doi: 10.1039/c4cc03077j. Epub 2014 May 22.
PMID:24850165
Abstract
Two "small" 22- and 24-membered exo-alcohol functionalised pyridyl macrocycles are exploited in the CuAAC active-template synthesis of [2]rotaxanes. The 24-membered macrocycle forms [2]rotaxanes in good yields while the smaller 22-membered macrocycle does not lead to interlocked products.
摘要
两个“小的”含有22和24个成员的外醇官能化吡啶基大环化合物被用于[2]轮烷的铜催化的叠氮-炔环加成活性模板合成中。24元大环化合物能以良好的产率形成[2]轮烷，而较小的22元大环化合物则不会产生互锁产物。
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