Milicević Nevenka, Mrcela Milanka, Lukić Ivana, Mandić Sanja, Horvat Vesna, Galić Josip
Coll Antropol. 2014 Mar;38(1):147-50.
The aim of the study was to clarify whether serum levels of proinflammatory cytokine interleukin-6 (IL-6) could be a useful marker in prostate diseases. Serum IL-6 was determined prior to prostate biopsy procedure in 82 patients with prostate adenocarcinoma (PCa), 25 patients with benign prostatic hyperplasia (BPH), 24 patients with high-grade prostatic intraepithelial neoplasia (PIN) and 17 patients with chronic prostatitis. Serum IL-6 levels were compared with total PSA (tPSA), free PSA (fPSA) and the free/total ratio (f/tPSA) serum levels. Statistically significant difference was not found in serum IL-6 levels among the four groups (p = 0.088). However, the patients with poorly differentiated PCa with Gleason score (GS) 4 + 3 = 7 and > 7 had significantly higher serum IL-6 levels than the patients with moderately differentiated PCa with GS 3 + 4 = 7 and < 7 (p = 0.007). The findings suggest that serum IL-6 level might be a potentially useful marker for poorly differentiated PCa.
该研究的目的是阐明促炎细胞因子白细胞介素-6（IL-6）的血清水平是否可能成为前列腺疾病的有用标志物。在前列腺活检前，对82例前列腺腺癌（PCa）患者、25例良性前列腺增生（BPH）患者、24例高级别前列腺上皮内瘤变（PIN）患者和17例慢性前列腺炎患者测定了血清IL-6。将血清IL-6水平与总前列腺特异性抗原（tPSA）、游离前列腺特异性抗原（fPSA）以及游离/总比值（f/tPSA）的血清水平进行比较。四组之间血清IL-6水平未发现统计学上的显著差异（p = 0.088）。然而，Gleason评分（GS）为4 + 3 = 7及> 7的低分化PCa患者的血清IL-6水平显著高于GS为3 + 4 = 7及< 7的中分化PCa患者（p = 0.007）。这些发现表明，血清IL-6水平可能是低分化PCa的一个潜在有用标志物。
