Meng Juan, Lu Yuewu, Dong Xin, Liu Hongyan
Department of Rheumatology & Immunology, Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Department of Rheumatology & Immunology, Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China. Email:
Zhonghua Yi Xue Za Zhi. 2014 Apr 8;94(13):965-8.
To observe the long-term effects of hydroxychloroquine treatment on blood lipids and left ventricular function of systemic lupus erythematosus (SLE) patients.
A total of 72 SLE patients were randomly divided into 2 groups of hydroxychloroquine treatment (n = 36) and non-hydroxychloroquine (n = 36). The serum level of lipids, left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), interventricular septum thickness (IVST), left ventricular posterior wall thickness (LVPWT), fractional shortening rate (FS), left ventricular ejection fraction (LVEF) and E/A ratio were measured before, 6 month, 12 month and 2 years after treatment.
After long-term use of hydroxychloroquine, there were statistically differences in the levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL). And LVEDD, LVWPT and E/A were statistically different (P < 0.05) before and after hydroxychloroquine dosing.
The long-term use of hydroxychloroquine may improve lipid metabolism and left ventricular function in SLE patients.
观察羟氯喹治疗对系统性红斑狼疮（SLE）患者血脂及左心室功能的长期影响。
将72例SLE患者随机分为羟氯喹治疗组（n = 36）和非羟氯喹组（n = 36）。于治疗前、治疗后6个月、12个月及2年测定血脂水平、左心室舒张末期内径（LVEDD）、左心室收缩末期内径（LVESD）、室间隔厚度（IVST）、左心室后壁厚度（LVPWT）、缩短分数（FS）、左心室射血分数（LVEF）及E/A比值。
长期使用羟氯喹后，总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）及高密度脂蛋白（HDL）水平有统计学差异。羟氯喹给药前后LVEDD、LVPWT及E/A有统计学差异（P < 0.05）。
长期使用羟氯喹可能改善SLE患者的脂质代谢及左心室功能。
