Chen Xumei, Zhu Qiyue, Zhang Wei, Li Xue, Hao Yihui, Li Youhui, Lü Luxian, Song Xueqin
Department of Psychiatry, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Department of the Second Affiliated Hospital, Xinxiang Medical University, Xinxiang 453002, China. Email:
Zhonghua Yi Xue Za Zhi. 2014 Apr 8;94(13):990-3.
To explore the correlation between serum levels of homocysteine (Hcy) and folate and cognitive function in first-episode drug-naїve schizophrenics.
A total of 60 first-episode schizophrenics (schizophrenia group) from our hospital and 60 healthy individuals (control group) were enrolled.Serum levels of folate and Hcy were measured with electrochemical luminescence method and enzymatic cycling assay respectively. Positive and Negative Syndrome Scale (PANSS) was used to evaluate the mental symptoms and Matrics Consensus Cognitive Battery (MCCB) was used to evaluate the cognitive function.
Serum level of folate in schizophrenia group (4.1 ± 1.9 ng/ml) was lower than that in control group (7.5 ± 1.9 ng/ml) (P < 0.001). And serum level of Hcy in schizophrenia group (27 ± 9 µmol/L) was significantly higher than that in control group (18 ± 6 µmol/L) (P = 0.006). Serum level of folate in schizophrenia group had negative correlations with Hcy level (r = -0.38, P = 0.002) and negative symptoms (r = -0.25, P < 0.05) while Hcy level was negatively correlated with cognitive function scores (r = -0.38, r = -0.33, r = -0.30, r = -0.30, P < 0.05).
Serum level of folate decreases while serum level of Hcy increases in first-episode schizophrenics. Both have some relevance with mental symptom and cognitive dysfunction.
探讨首发未用药精神分裂症患者血清同型半胱氨酸（Hcy）和叶酸水平与认知功能之间的相关性。
选取我院60例首发精神分裂症患者（精神分裂症组）和60例健康个体（对照组）。分别采用电化学发光法和酶循环法检测血清叶酸和Hcy水平。采用阳性与阴性症状量表（PANSS）评估精神症状，采用矩阵共识认知成套测验（MCCB）评估认知功能。
精神分裂症组血清叶酸水平（4.1±1.9 ng/ml）低于对照组（7.5±1.9 ng/ml）（P<0.001）。精神分裂症组血清Hcy水平（27±9 μmol/L）显著高于对照组（18±6 μmol/L）（P=0.006）。精神分裂症组血清叶酸水平与Hcy水平呈负相关（r=-0.38，P=0.002），与阴性症状呈负相关（r=-0.25，P<0.05），而Hcy水平与认知功能评分呈负相关（r=-0.38，r=-0.33，r=-0.30，r=-0.30，P<0.05）。
首发精神分裂症患者血清叶酸水平降低，血清Hcy水平升高。二者均与精神症状及认知功能障碍有一定相关性。
