Lindestam Arlehamn Cecilia S, Lewinsohn David, Sette Alessandro, Lewinsohn Deborah
La Jolla Institute for Allergy and Immunology, La Jolla, California 92037.
Oregon Health and Science University, Portland, Oregon 97239 Portland VA Medical Center, Portland, Oregon 97239.
Cold Spring Harb Perspect Med. 2014 May 22;4(7):a018465. doi: 10.1101/cshperspect.a018465.
Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (MTB), represents an important cause of morbidity and mortality worldwide for which an improved vaccine and immunodiagnostics are urgently needed. CD4(+) and CD8(+) T cells play an important role in host defense to TB. Definition of the antigens recognized by these T cells is critical for improved understanding of the immunobiology of TB and for development of vaccines and diagnostics. Herein, the antigens and epitopes recognized by classically HLA class I- and II-restricted CD4(+) and CD8(+) T cells in humans infected with MTB are reviewed. Immunodominant antigens and epitopes have been defined using approaches targeting particular TB proteins or classes of proteins and by genome-wide discovery approaches. Antigens and epitopes recognized by classically restricted CD4(+) and CD8(+) T cells show extensive breadth and diversity in MTB-infected humans.
结核病（TB）由结核分枝杆菌（MTB）感染引起，是全球发病和死亡的重要原因，因此迫切需要改进疫苗和免疫诊断方法。CD4(+)和CD8(+) T细胞在宿主抗结核防御中发挥重要作用。确定这些T细胞识别的抗原对于更好地理解结核病的免疫生物学以及疫苗和诊断方法的开发至关重要。本文综述了MTB感染人类中经典的HLA I类和II类限制性CD4(+)和CD8(+) T细胞识别的抗原和表位。已使用针对特定结核蛋白或蛋白类别的方法以及全基因组发现方法确定了免疫显性抗原和表位。在MTB感染的人类中，经典限制性CD4(+)和CD8(+) T细胞识别的抗原和表位显示出广泛的广度和多样性。
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