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Intra-individual, randomised comparison of the MRI contrast agents gadobutrol versus gadoteridol in patients with primary and secondary brain tumours, evaluated in a blinded read.在一项盲法评估中，对原发性和继发性脑肿瘤患者进行了个体内、随机对照比较，评估了 MRI 对比剂钆布醇与钆特醇的效果。
Eur Radiol. 2013 Dec;23(12):3287-95. doi: 10.1007/s00330-013-2946-3. Epub 2013 Jul 4.
2
Multicenter, intra-individual comparison of single dose gadobenate dimeglumine and double dose gadopentetate dimeglumine for MR angiography of the peripheral arteries (the Peripheral VALUE Study).多中心、个体内对照研究单次剂量钆贝葡胺与双倍剂量钆喷替酸葡甲胺在四肢动脉磁共振血管成像中的应用（Peripheral VALUE 研究）。
J Magn Reson Imaging. 2013 Oct;38(4):926-37. doi: 10.1002/jmri.24040. Epub 2013 Jan 31.
3
Effect of abrupt substitution of gadobenate dimeglumine for gadopentetate dimeglumine on rate of allergic-like reactions.突换钆贝葡胺对比钆喷替酸葡胺对过敏样反应发生率的影响。
Radiology. 2013 Mar;266(3):773-82. doi: 10.1148/radiol.12120253. Epub 2012 Dec 13.
4
Dynamic and static magnetic resonance angiography of the supra-aortic vessels at 3.0 T: intraindividual comparison of gadobutrol, gadobenate dimeglumine, and gadoterate meglumine at equimolar dose.3.0T 上主动脉血管的动态和静态磁共振血管造影：等摩尔剂量下钆布醇、钆贝葡胺和钆特酸葡胺的个体内比较。
Invest Radiol. 2013 Mar;48(3):121-8. doi: 10.1097/RLI.0b013e31827752b4.
5
Multicenter, intraindividual comparison of single-dose gadobenate dimeglumine and double-dose gadopentetate dimeglumine for MR angiography of the supra-aortic arteries (the Supra-Aortic VALUE study).多中心、个体内比较单剂量钆贝葡胺和双剂量钆喷替酸葡甲胺用于主动脉上动脉磁共振血管成像（Supra-Aortic VALUE 研究）。
AJNR Am J Neuroradiol. 2013 Apr;34(4):847-54. doi: 10.3174/ajnr.A3298. Epub 2012 Oct 4.
6
Objective evaluation of acute adverse events and image quality of gadolinium-based contrast agents (gadobutrol and gadobenate dimeglumine) by blinded evaluation. Pilot study.目的评价盲法评估下基于钆的对比剂（钆布醇和钆贝葡胺）的急性不良反应和图像质量。初步研究。
Magn Reson Imaging. 2013 Jan;31(1):96-101. doi: 10.1016/j.mri.2012.06.025. Epub 2012 Aug 13.
7
Gadolinium-induced nephrogenic systemic fibrosis: the rise and fall of an iatrogenic disease.钆诱导的肾源性系统性纤维化：一种医源性疾病的兴衰。
Clin Kidney J. 2012 Feb;5(1):82-88. doi: 10.1093/ckj/sfr172.
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Immediate hypersensitivity reaction to gadolinium-based MR contrast media.立即对钆基磁共振对比剂产生超敏反应。
Radiology. 2012 Aug;264(2):414-22. doi: 10.1148/radiol.12112025. Epub 2012 May 1.
9
Does higher gadolinium concentration play a role in the morphologic assessment of brain tumors? Results of a multicenter intraindividual crossover comparison of gadobutrol versus gadobenate dimeglumine (the MERIT Study).更高的钆浓度是否在脑肿瘤的形态评估中发挥作用？对比钆布醇和钆贝葡胺（MERIT 研究）多中心个体内交叉比较的结果。
AJNR Am J Neuroradiol. 2012 Jun;33(6):1050-8. doi: 10.3174/ajnr.A3033. Epub 2012 Mar 1.
10
Acute adverse reactions to gadolinium-based contrast agents in CMR: multicenter experience with 17,767 patients from the EuroCMR Registry.CMR 中钆基对比剂的急性不良反应：来自 EuroCMR 注册中心的 17767 例患者的多中心经验。
JACC Cardiovasc Imaging. 2011 Nov;4(11):1171-6. doi: 10.1016/j.jcmg.2011.06.019.

用于中枢神经系统成像的钆对比剂：当前概念与临床证据

Gadolinium contrast agents for CNS imaging: current concepts and clinical evidence.

作者信息

Kanal E, Maravilla K, Rowley H A

机构信息

From Magnetic Resonance Services (E.K.), Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Research Laboratory (K.M.), University of Washington, Seattle, Washington.

出版信息

AJNR Am J Neuroradiol. 2014 Dec;35(12):2215-26. doi: 10.3174/ajnr.A3917. Epub 2014 May 22.

DOI:10.3174/ajnr.A3917
PMID:24852287
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7965302/
Abstract

The aim of this article was to review the properties of the various gadolinium-based contrast agents used for CNS imaging along with the clinical evidence and published data that highlight the impact these different properties can have on diagnostic performance. In addition, approaches to optimizing image acquisition that take into account the different properties of specific gadolinium-based contrast agents and an extensive review of the safety profiles of the various agents are presented.

摘要

本文的目的是回顾用于中枢神经系统成像的各种钆基造影剂的特性，以及突出这些不同特性对诊断性能可能产生的影响的临床证据和已发表数据。此外，还介绍了考虑特定钆基造影剂不同特性的优化图像采集方法，以及对各种造影剂安全性概况的广泛综述。