用于中枢神经系统成像的钆对比剂：当前概念与临床证据
Gadolinium contrast agents for CNS imaging: current concepts and clinical evidence.
作者信息
Kanal E, Maravilla K, Rowley H A
机构信息
From Magnetic Resonance Services (E.K.), Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Research Laboratory (K.M.), University of Washington, Seattle, Washington.
出版信息
AJNR Am J Neuroradiol. 2014 Dec;35(12):2215-26. doi: 10.3174/ajnr.A3917. Epub 2014 May 22.
Abstract
The aim of this article was to review the properties of the various gadolinium-based contrast agents used for CNS imaging along with the clinical evidence and published data that highlight the impact these different properties can have on diagnostic performance. In addition, approaches to optimizing image acquisition that take into account the different properties of specific gadolinium-based contrast agents and an extensive review of the safety profiles of the various agents are presented.
摘要
本文的目的是回顾用于中枢神经系统成像的各种钆基造影剂的特性，以及突出这些不同特性对诊断性能可能产生的影响的临床证据和已发表数据。此外，还介绍了考虑特定钆基造影剂不同特性的优化图像采集方法，以及对各种造影剂安全性概况的广泛综述。
相似文献
1
Gadolinium contrast agents for CNS imaging: current concepts and clinical evidence.用于中枢神经系统成像的钆对比剂：当前概念与临床证据
AJNR Am J Neuroradiol. 2014 Dec;35(12):2215-26. doi: 10.3174/ajnr.A3917. Epub 2014 May 22.
2
Synthesizing a Contrast-Enhancement Map in Patients with High-Grade Gliomas Based on a Postcontrast MR Imaging Quantification Only.仅基于增强后磁共振成像定量分析合成高级别脑胶质瘤患者的对比增强图谱。
AJNR Am J Neuroradiol. 2018 Dec;39(12):2194-2199. doi: 10.3174/ajnr.A5870. Epub 2018 Nov 8.
3
Advances in magnetic resonance (2008).磁共振成像进展（2008年）
Invest Radiol. 2008 Dec;43(12):893-8. doi: 10.1097/RLI.0b013e31818e659e.
4
Effect of Gadolinium on the Estimation of Myelin and Brain Tissue Volumes Based on Quantitative Synthetic MRI.基于定量合成 MRI 的钆剂对髓鞘和脑组织体积估计的影响。
AJNR Am J Neuroradiol. 2019 Feb;40(2):231-237. doi: 10.3174/ajnr.A5921. Epub 2018 Dec 27.
5
Perfusion MRI: the five most frequently asked clinical questions.灌注 MRI：五个最常被问到的临床问题。
AJR Am J Roentgenol. 2013 Sep;201(3):W495-510. doi: 10.2214/AJR.12.9544.
6
Unilateral Nonvisualization of a Transverse Dural Sinus on Phase-Contrast MRV: Frequency and Differentiation from Sinus Thrombosis on Noncontrast MRI.磁共振静脉血管成像相位对比技术中单侧横窦未显影：在非对比 MRI 上与窦血栓形成的鉴别诊断及发生率。
AJNR Am J Neuroradiol. 2020 Jan;41(1):115-121. doi: 10.3174/ajnr.A6337.
7
Complementary Roles of Dynamic Contrast-Enhanced MR Imaging and Postcontrast Vessel Wall Imaging in Detecting High-Risk Intracranial Aneurysms.动态对比增强磁共振成像与增强后血管壁成像在检测高风险颅内动脉瘤中的互补作用。
AJNR Am J Neuroradiol. 2019 Mar;40(3):490-496. doi: 10.3174/ajnr.A5983. Epub 2019 Feb 21.
8
Usefulness of High Resolution T2-Weighted Images in the Evaluation and Surveillance of Vestibular Schwannomas? Is Gadolinium Needed?高分辨率T2加权图像在前庭神经鞘瘤评估和监测中的作用？是否需要钆剂？
Otol Neurotol. 2020 Jan;41(1):e103-e110. doi: 10.1097/MAO.0000000000002436.
9
Liver acquisition with acceleration volume acquisition gadolinium-enhanced magnetic resonance combined with T2 sequences in the diagnosis of local recurrence of rectal cancer.加速采集容积采集钆增强磁共振结合 T2 序列在直肠癌局部复发诊断中的应用。
J Xray Sci Technol. 2016 Nov 22;24(6):855-863. doi: 10.3233/XST-160594.
10
Safe and optimized use of gadolinium-based contrast agents in neuroimaging.钆基造影剂在神经成像中的安全与优化使用。
Eur Radiol. 2024 Jul;34(7):4567-4569. doi: 10.1007/s00330-023-10456-y. Epub 2023 Nov 25.
引用本文的文献
1
Safety Evaluation of Omniscan: An Observational Postmarketing Surveillance.欧乃影的安全性评估：一项上市后观察性监测
Cureus. 2025 Jul 31;17(7):e89184. doi: 10.7759/cureus.89184. eCollection 2025 Jul.
2
Evolving Characteristics of Gadolinium-Based Contrast Agents for MR Imaging: A Systematic Review of the Importance of Relaxivity.用于磁共振成像的钆基造影剂的演变特征：关于弛豫率重要性的系统评价
J Magn Reson Imaging. 2025 Jan;61(1):52-69. doi: 10.1002/jmri.29367. Epub 2024 May 3.
3
Improved reproducibility for myocardial ASL: Impact of physiological and acquisition parameters.提高心肌动脉自旋标记的可重复性：生理和采集参数的影响。
Magn Reson Med. 2024 Jan;91(1):118-132. doi: 10.1002/mrm.29834. Epub 2023 Sep 5.
4
Current practices and perspectives on the integration of contrast agents in MRI-guided radiation therapy clinical practice: A worldwide survey.磁共振成像引导放射治疗临床实践中造影剂整合的当前实践与观点：一项全球调查。
Clin Transl Radiat Oncol. 2023 Mar 8;40:100615. doi: 10.1016/j.ctro.2023.100615. eCollection 2023 May.
5
The TRUTH confirmed: validation of an intraindividual comparison of gadobutrol and gadoteridol for imaging of glioblastoma using quantitative enhancement analysis.真相大白：使用定量增强分析对脑胶质母细胞瘤成像的钆布醇和钆喷酸葡胺个体内比较的验证。
Eur Radiol Exp. 2021 Oct 12;5(1):46. doi: 10.1186/s41747-021-00240-2.
6
Diffusion Tensor Imaging of the Dentate Nucleus After Repeated Administration of Gadobutrol in Children.重复使用钆布醇后齿状核的弥散张量成像。
Cerebellum. 2022 Aug;21(4):657-664. doi: 10.1007/s12311-021-01324-w. Epub 2021 Aug 27.
7
Dose-Lowering in Contrast-Enhanced MRI of the Central Nervous System: A Retrospective, Parallel-Group Comparison Using Gadobenate Dimeglumine.中枢神经系统对比增强 MRI 的剂量降低：使用钆贝葡胺的回顾性、平行组比较。
J Magn Reson Imaging. 2021 Nov;54(5):1660-1675. doi: 10.1002/jmri.27731. Epub 2021 May 20.
8
Twofold improved tumor-to-brain contrast using a novel T1 relaxation-enhanced steady-state (TRESS) MRI technique.使用一种新型的T1弛豫增强稳态（TRESS）MRI技术使肿瘤与脑的对比度提高了两倍。
Sci Adv. 2020 Oct 28;6(44). doi: 10.1126/sciadv.abd1635. Print 2020 Oct.
9
Randomized study of the effect of gadopiclenol, a new gadolinium-based contrast agent, on the QTc interval in healthy subjects.新型钆基造影剂加多酸对健康受试者QTc间期影响的随机研究。
Br J Clin Pharmacol. 2020 Nov;86(11):2174-2181. doi: 10.1111/bcp.14309. Epub 2020 Apr 27.
10
Six-dimensional quantitative DCE MR Multitasking of the entire abdomen: Method and application to pancreatic ductal adenocarcinoma.全腹部六维定量动态对比增强磁共振多任务成像：方法及其在胰腺导管腺癌中的应用
Magn Reson Med. 2020 Aug;84(2):928-948. doi: 10.1002/mrm.28167. Epub 2020 Jan 21.
本文引用的文献
1
Intra-individual, randomised comparison of the MRI contrast agents gadobutrol versus gadoteridol in patients with primary and secondary brain tumours, evaluated in a blinded read.在一项盲法评估中，对原发性和继发性脑肿瘤患者进行了个体内、随机对照比较，评估了 MRI 对比剂钆布醇与钆特醇的效果。
Eur Radiol. 2013 Dec;23(12):3287-95. doi: 10.1007/s00330-013-2946-3. Epub 2013 Jul 4.
2
Multicenter, intra-individual comparison of single dose gadobenate dimeglumine and double dose gadopentetate dimeglumine for MR angiography of the peripheral arteries (the Peripheral VALUE Study).多中心、个体内对照研究单次剂量钆贝葡胺与双倍剂量钆喷替酸葡甲胺在四肢动脉磁共振血管成像中的应用（Peripheral VALUE 研究）。
J Magn Reson Imaging. 2013 Oct;38(4):926-37. doi: 10.1002/jmri.24040. Epub 2013 Jan 31.
3
Effect of abrupt substitution of gadobenate dimeglumine for gadopentetate dimeglumine on rate of allergic-like reactions.突换钆贝葡胺对比钆喷替酸葡胺对过敏样反应发生率的影响。
Radiology. 2013 Mar;266(3):773-82. doi: 10.1148/radiol.12120253. Epub 2012 Dec 13.
4
Dynamic and static magnetic resonance angiography of the supra-aortic vessels at 3.0 T: intraindividual comparison of gadobutrol, gadobenate dimeglumine, and gadoterate meglumine at equimolar dose.3.0T 上主动脉血管的动态和静态磁共振血管造影：等摩尔剂量下钆布醇、钆贝葡胺和钆特酸葡胺的个体内比较。
Invest Radiol. 2013 Mar;48(3):121-8. doi: 10.1097/RLI.0b013e31827752b4.
5
Multicenter, intraindividual comparison of single-dose gadobenate dimeglumine and double-dose gadopentetate dimeglumine for MR angiography of the supra-aortic arteries (the Supra-Aortic VALUE study).多中心、个体内比较单剂量钆贝葡胺和双剂量钆喷替酸葡甲胺用于主动脉上动脉磁共振血管成像（Supra-Aortic VALUE 研究）。
AJNR Am J Neuroradiol. 2013 Apr;34(4):847-54. doi: 10.3174/ajnr.A3298. Epub 2012 Oct 4.
6
Objective evaluation of acute adverse events and image quality of gadolinium-based contrast agents (gadobutrol and gadobenate dimeglumine) by blinded evaluation. Pilot study.目的评价盲法评估下基于钆的对比剂（钆布醇和钆贝葡胺）的急性不良反应和图像质量。初步研究。
Magn Reson Imaging. 2013 Jan;31(1):96-101. doi: 10.1016/j.mri.2012.06.025. Epub 2012 Aug 13.
7
Gadolinium-induced nephrogenic systemic fibrosis: the rise and fall of an iatrogenic disease.钆诱导的肾源性系统性纤维化：一种医源性疾病的兴衰。
Clin Kidney J. 2012 Feb;5(1):82-88. doi: 10.1093/ckj/sfr172.
8
Immediate hypersensitivity reaction to gadolinium-based MR contrast media.立即对钆基磁共振对比剂产生超敏反应。
Radiology. 2012 Aug;264(2):414-22. doi: 10.1148/radiol.12112025. Epub 2012 May 1.
9
Does higher gadolinium concentration play a role in the morphologic assessment of brain tumors? Results of a multicenter intraindividual crossover comparison of gadobutrol versus gadobenate dimeglumine (the MERIT Study).更高的钆浓度是否在脑肿瘤的形态评估中发挥作用？对比钆布醇和钆贝葡胺（MERIT 研究）多中心个体内交叉比较的结果。
AJNR Am J Neuroradiol. 2012 Jun;33(6):1050-8. doi: 10.3174/ajnr.A3033. Epub 2012 Mar 1.
10
Acute adverse reactions to gadolinium-based contrast agents in CMR: multicenter experience with 17,767 patients from the EuroCMR Registry.CMR 中钆基对比剂的急性不良反应：来自 EuroCMR 注册中心的 17767 例患者的多中心经验。
JACC Cardiovasc Imaging. 2011 Nov;4(11):1171-6. doi: 10.1016/j.jcmg.2011.06.019.
Zotero 插件