从轻度认知障碍到痴呆症的进展：一项为期3年的纵向研究。
Progression from mild cognitive impairment to dementia: a 3-year longitudinal study.
作者信息
Brodaty Henry, Connors Michael H, Ames David, Woodward Michael
机构信息
Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia
Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
出版信息
Aust N Z J Psychiatry. 2014 Dec;48(12):1137-42. doi: 10.1177/0004867414536237. Epub 2014 May 22.
OBJECTIVE
To examine characteristics that predict the progression from mild cognitive impairment to dementia.
METHODS
Of 970 patients recruited from nine memory clinics around Australia, 185 had mild cognitive impairment diagnosed. Measures of cognitive ability, functional ability, and neuropsychiatric symptoms were completed at baseline and over 3 years of follow up.
RESULTS
Over 3 years, 52 (28%) patients with mild cognitive impairment developed dementia. Older age, lower cognitive ability at baseline, and faster decline in cognitive ability over the first 6 months of follow up, but not depression, predicted progression to dementia.
CONCLUSIONS
The findings confirm that simple clinical data such as age, cognitive ability at baseline, and rate of cognitive decline are important predictors of progression from mild cognitive impairment to dementia over 3 years.
目的
研究预测从轻度认知障碍进展为痴呆的特征。
方法
在从澳大利亚各地九家记忆诊所招募的970名患者中，185名被诊断为轻度认知障碍。在基线时以及随访的3年期间完成了认知能力、功能能力和神经精神症状的测量。
结果
在3年期间，52名（28%）轻度认知障碍患者发展为痴呆。年龄较大、基线时认知能力较低以及随访前6个月认知能力下降较快，但不是抑郁，可预测进展为痴呆。
结论
研究结果证实，诸如年龄、基线时的认知能力和认知下降速度等简单临床数据是3年内从轻度认知障碍进展为痴呆的重要预测因素。
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