中国老年人肌肉减少症与心理健康状况的关系：日常生活活动的中介作用。
The relationship between sarcopenia and mental health status in Chinese older adults: the mediating role of activities of daily living.
作者信息
Ge Huaiju, Yang Shilan, Su Wenyu, Guan Weimin, Dong Shihong, Chang Wenjing, Jia Huiyu, Jiang Shan, Qin Di, Ma Guifeng
机构信息
School of Public Health, Shandong Second Medical University, Weifang, Shandong, China.
School of Bioscience and Technology, Shandong Second Medical University, Weifang, Shandong, China.
出版信息
BMC Geriatr. 2025 Jan 29;25(1):64. doi: 10.1186/s12877-025-05723-0.
BACKGROUND
Most existing studies focus on either the relationship between sarcopenia and depressive symptoms or sarcopenia and cognitive functions. Few studies have examined depressive symptoms and cognitive functions simultaneously. This study aimed to analyze the relationship between sarcopenia and both depressive symptoms and cognitive functions in the elderly by introducing activities of daily living to explore the mediating role of activities of daily living between sarcopenia and mental health.
METHODS
This study used data from the 2015 and 2018 China Health and Retirement Longitudinal Study, including a total of 3,552 older adults aged 60 and above. We conducted descriptive statistical analysis and correlation analysis on the data and used seemingly unrelated regression to examine the relationship between sarcopenia, depressive symptoms, and cognitive functions in older adults. Bootstrap mediation analysis was used to further explore the mediating role of activities of daily living in the relationship between sarcopenia and depressive symptoms and cognitive functions in the elderly.
RESULTS
After adjusting for confounding factors, sarcopenia was positively correlated with depressive symptoms (β = 0.663, p < 0.001) and negatively correlated with cognitive functions (β=-0.748, p < 0.001), indicating a negative impact of sarcopenia on mental health. Activities of daily living mediated the relationship between sarcopenia and mental health, with a stronger mediating effect between sarcopenia and depressive symptoms (18.77%, β = 0.125, 95%CI (0.035, 0.222)) than between sarcopenia and cognitive functions (12.82%, β=-0.099, 95%CI (-0.162, -0.035)).
CONCLUSIONS
Activities of daily living partially mediated the relationship between sarcopenia and mental health status in Chinese older adults. Interventions targeting sarcopenia and activities of daily living may be an effective way to prevent and improve the mental health status of older adults.
背景
大多数现有研究要么聚焦于肌肉减少症与抑郁症状之间的关系，要么关注肌肉减少症与认知功能之间的关系。很少有研究同时考察抑郁症状和认知功能。本研究旨在通过引入日常生活活动来分析老年人肌肉减少症与抑郁症状和认知功能之间的关系，以探讨日常生活活动在肌肉减少症与心理健康之间的中介作用。
方法
本研究使用了2015年和2018年中国健康与养老追踪调查的数据，共纳入3552名60岁及以上的老年人。我们对数据进行了描述性统计分析和相关性分析，并使用看似不相关回归来检验老年人肌肉减少症、抑郁症状和认知功能之间的关系。采用Bootstrap中介分析进一步探讨日常生活活动在老年人肌肉减少症与抑郁症状和认知功能关系中的中介作用。
结果
在调整混杂因素后，肌肉减少症与抑郁症状呈正相关（β = 0.663，p < 0.001），与认知功能呈负相关（β = -0.748，p < 0.001），表明肌肉减少症对心理健康有负面影响。日常生活活动介导了肌肉减少症与心理健康之间的关系，其在肌肉减少症与抑郁症状之间的中介作用（18.77%，β = 0.125，95%CI（0.035，0.222））强于在肌肉减少症与认知功能之间的中介作用（12.82%，β = -0.099，95%CI（-0.162，-0.035））。
结论
日常生活活动部分介导了中国老年人肌肉减少症与心理健康状况之间的关系。针对肌肉减少症和日常生活活动的干预措施可能是预防和改善老年人心理健康状况的有效途径。
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