*Dermatology Department, National Institute of Laser Enhanced Science, Cairo University, Cairo, Egypt; †Dermatology Department, National Center for Radiation Research and Technology, Cairo, Egypt; ‡Histology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Dermatol Surg. 2014 Jun;40(6):632-40. doi: 10.1111/dsu.0000000000000007.
Pulsed dye laser (PDL) and intense pulsed light (IPL) have been used to treat striae distensae.
To compare the difference between the treatment efficacy of PDL and IPL on striae distensae.
Twenty patients with age ranging from 15 to 42 years were included in this study. All patients were treated on one side of their bodies with PDL and on the other side with IPL for 5 sessions with a 4-week interval between the sessions. Skin biopsies were stained with hematoxylin and eosin, Masson trichrome, orcein, Alcian blue, and anticollagen I α1.
After both PDL and IPL, striae width was decreased and skin texture was improved in a highly significant manner. Collagen expression was increased in a highly significant manner after PDL and IPL. However, PDL induced the expression of collagen I in a highly significant manner compared with IPL, where p values were <.001 and .193, respectively. Striae rubra gave a superior response with either PDL or IPL compared with striae alba, which was evaluated clinically by the width, color, and texture, although the histological changes could not verify this consequence.
Both PDL and IPL can enhance the clinical picture of striae through collagen stimulation.
脉冲染料激光（PDL）和强脉冲光（IPL）已被用于治疗膨胀纹。
比较 PDL 和 IPL 治疗膨胀纹的疗效差异。
本研究纳入 20 例年龄在 15 至 42 岁之间的患者。所有患者均接受 5 次治疗，每 4 周间隔一次，一侧采用 PDL 治疗，另一侧采用 IPL 治疗。皮肤活检标本行苏木精-伊红、Masson 三色、奥辛蓝、抗胶原蛋白 Iα1 染色。
PDL 和 IPL 治疗后，纹宽显著减小，皮肤质地显著改善。胶原表达显著增加。然而，与 IPL 相比，PDL 诱导 I 型胶原表达的程度更高，p 值分别为<.001 和.193。与白色纹相比，红色纹对 PDL 或 IPL 的反应更好，这在临床评估时通过纹宽、颜色和质地来判断，尽管组织学变化无法证实这一结果。
PDL 和 IPL 均可通过刺激胶原来改善膨胀纹的临床外观。
