用于半胱氨酸修饰、二硫键桥连及二硫键双功能化的芳氧基马来酰亚胺。
Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds.
作者信息
Marculescu Cristina, Kossen Hanno, Morgan Rachel E, Mayer Patrick, Fletcher Sally A, Tolner Berend, Chester Kerry A, Jones Lyn H, Baker James R
机构信息
Department of Chemistry, University College London, 20 Gordon St, London, UK.
出版信息
Chem Commun (Camb). 2014 Jul 11;50(54):7139-42. doi: 10.1039/c4cc02107j.
PMID:24853662
Abstract
Tuning the properties of maleimide reagents holds significant promise in expanding the toolbox of available methods for bioconjugation. Herein we describe aryloxymaleimides which represent 'next generation maleimides' of attenuated reactivity, and demonstrate their ability to enable new methods for protein modification at disulfide bonds.
摘要
调节马来酰亚胺试剂的性质对于扩充现有的生物共轭方法工具库具有重大前景。在此，我们描述了芳氧基马来酰亚胺，它们代表了反应活性减弱的“新一代马来酰亚胺”，并展示了它们实现二硫键处蛋白质修饰新方法的能力。
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