高效二硫键桥联聚合物，用于自由基相容的二噻吩酚马来酰亚胺生物缀合物。
Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides.
机构信息
Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL.
出版信息
Chem Commun (Camb). 2012 Apr 28;48(34):4064-6. doi: 10.1039/c2cc30259d. Epub 2012 Mar 21.
PMID:22436767
Abstract
The direct synthesis of dithiophenol maleimide functional polymers by living radical polymerisation is described without the need for protecting group chemistry. The synthesised polymers have been successfully employed as disulfide bridging agents for salmon calcitonin when used in equimolar quantities, negating the requirement for complex purification strategies, traditionally associated with peptide bioconjugation.
摘要
通过活性自由基聚合，在无需保护基团化学的情况下直接合成二噻吩酚马来酰亚胺功能聚合物。当使用等摩尔量时，所合成的聚合物已成功用作鲑鱼降钙素的二硫键桥连试剂，从而消除了与肽生物缀合相关的传统复杂纯化策略的需求。
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