Tanaka A, Shima K, Fukuda M, Tahara Y, Yamamoto Y, Kumahara Y
Med J Osaka Univ. 1989 Mar;38(1-4):57-63.
Renal tubular function was investigated in 98 non-insulin-dependent and 18 insulin-dependent diabetics under conditions of standard glycemic control. Mean urinary excretion of lysozyme, beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase (NAG) in both Albustix-negative and positive patients were significantly elevated above the control range. The increased excretion of lysozyme, beta 2-microglobulin and NAG was found in 21, 55 and 62% of the normoalbuminuric patients, and in 40, 57 and 74% of the microalbuminuric patients, respectively. Besides the parameters cited above, urinary acid-soluble glycoprotein (ASP) was measured to assess its potential as an indicator of early renal dysfunction. Mean urinary ASP excretion was also elevated in both Albustix-negative and positive patients. The albumin/ASP ratio increased as nephropathy advanced. Such a mode of excretion was similar to those of low-molecular-weight proteins (lysozyme and beta 2-microglobulin). The results of multiple regression analysis showed that serum creatinine most highly correlated with the excretion of the urinary proteins except for NAG.
在标准血糖控制条件下，对98例非胰岛素依赖型糖尿病患者和18例胰岛素依赖型糖尿病患者的肾小管功能进行了研究。在Albustix阴性和阳性患者中，溶菌酶、β2-微球蛋白和N-乙酰-β-D-氨基葡萄糖苷酶（NAG）的平均尿排泄量均显著高于对照范围。在正常白蛋白尿患者中，溶菌酶、β2-微球蛋白和NAG排泄增加的比例分别为21%、55%和62%，在微量白蛋白尿患者中分别为40%、57%和74%。除上述参数外，还检测了尿酸溶性糖蛋白（ASP），以评估其作为早期肾功能障碍指标的潜力。在Albustix阴性和阳性患者中，平均尿ASP排泄量也升高。随着肾病进展，白蛋白/ASP比值升高。这种排泄模式与低分子量蛋白质（溶菌酶和β2-微球蛋白）相似。多元回归分析结果显示，除NAG外，血清肌酐与尿蛋白排泄的相关性最高。
