Wachsberg Kelley N, Creden Amanda, Workman Moira, Lichten Abbey, Basil Alka, Lee Jungwha, Peng Jie, Williams Mark V, Kushner Robert F
Division of Hospital Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
J Hosp Med. 2014 Aug;9(8):515-20. doi: 10.1002/jhm.2215. Epub 2014 May 23.
Obesity-related comorbidities frequently contribute to acute illness. Obesity interventions during hospitalization are not often utilized but may be effective.
To examine whether inpatient weight loss intervention with postdischarge follow-up results in weight loss at 6 months when compared to control.
Prospective, randomized controlled trial.
Academic medical center in Chicago, Illinois.
Obese adult inpatients.
Intervention subjects viewed a weight education video, underwent personalized counseling, and set specific weight loss, dietary, and fitness goals prior to discharge. All participants were followed by phone over the subsequent 6 months. The trial was unblinded to participants, physicians, and investigators.
Primary outcome was weight change between groups at 6 months. Weight change from baseline and waist-to-hip ratios (WHR) were also assessed.
For 176 participants in the intention-to-treat analysis, mean baseline weight for the intervention group was 107.7 kg (standard deviation [SD]=16.7) and 105.1 kg (SD=17.4) for controls. Mean weight loss at 6 months was 1.08 kg (SD=4.33) for intervention subjects and 1.35 kg (SD=3.65) among controls. There was no significant difference in weight loss between groups at 6 months (P=0.26). As-treated analysis yielded similar results. There were no differences in WHRs between the intervention and control at 6 months (0.04 vs 0.04, P=0.59).
We found no difference in weight loss between the intervention and control groups at 6 months.
肥胖相关的合并症常导致急性疾病。住院期间的肥胖干预措施虽不常使用，但可能有效。
探讨与对照组相比，住院期间体重减轻干预及出院后随访在6个月时是否能实现体重减轻。
前瞻性随机对照试验。
伊利诺伊州芝加哥的学术医疗中心。
肥胖成年住院患者。
干预组受试者在出院前观看了体重教育视频，接受了个性化咨询，并设定了具体的体重减轻、饮食和健身目标。在随后的6个月里，所有参与者都接受了电话随访。该试验对参与者、医生和研究人员未设盲。
主要结局是6个月时两组间的体重变化。还评估了与基线相比的体重变化以及腰臀比（WHR）。
在意向性分析的176名参与者中，干预组的平均基线体重为107.7千克（标准差[SD]=16.7），对照组为105.1千克（SD=17.4）。干预组受试者6个月时的平均体重减轻为1.08千克（SD=4.33），对照组为1.35千克（SD=3.65）。6个月时两组间体重减轻无显著差异（P=0.26）。实际治疗分析得出了类似结果。6个月时，干预组和对照组的腰臀比无差异（0.04对0.04，P=0.59）。
我们发现干预组和对照组在6个月时体重减轻没有差异。
