Yang P
First Clinical College, Hunan Medical University, Changsha.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1989;24(6):324-5, 384.
The effect of histamine on the capillary permeability of the nasal mucosa was studied quantitatively in normal rats using the Evans blue technique. The content of Evans blue in terms of ng per mg of nasal mucosa was significantly (P less than 0.001) higher in histamine group than that in control group, and reached peak value five minutes after injection of histamine at the concentration of 10(-8) mol/L. It is thought that this preliminary result might be useful in selecting optimal concentration of the challenge agent and the optimal time to evaluate the reaction.
采用伊文思蓝技术，对正常大鼠鼻黏膜毛细血管通透性进行了定量研究。组胺组鼻黏膜每毫克中伊文思蓝含量（以纳克计）显著高于对照组（P<0.001），且在注射浓度为10^(-8)摩尔/升的组胺后5分钟达到峰值。认为这一初步结果可能有助于选择激发剂的最佳浓度和评估反应的最佳时间。
