Liu Meiying, Zhang Xiqi, Yang Bin, Liu Liangji, Deng Fengjie, Zhang Xiaoyong, Wei Yen
Department of Chemistry/Institute of Polymers, Nanchang University, 999 Xuefu Avenue, Nanchang, 330031, China.
Macromol Biosci. 2014 Sep;14(9):1260-7. doi: 10.1002/mabi.201400140. Epub 2014 May 22.
Fluorescent organic nanoparticles based on aggregation induced emission dyes are fabricated through a ring-opening reaction using polylysine as the linker. The fluorescent organic nanoparticles obtained are characterized by a series of techniques including UV-vis absorption spectroscopy, fluorescence spectroscopy, Fourier Transform infrared spectroscopy, and transmission electron microscopy. A biocompatibility evaluation and the cell uptake behavior of the fluorescent organic nanoparticles are further investigated to evaluate their potential biomedical applications. It is demonstrated that these fluorescent organic nanoparticles can be obtained at room temperature in an air atmosphere without the need for catalyst or initiator. Furthermore, these crosslinked aggregation induced emission dye based fluorescent organic nanoparticles show uniform morphology, strong red fluorescence, high water dispersability, and excellent biocompatibility, making them promising candidates for various biomedical applications.
基于聚集诱导发光染料的荧光有机纳米颗粒通过以聚赖氨酸为连接剂的开环反应制备而成。所获得的荧光有机纳米颗粒通过一系列技术进行表征，包括紫外可见吸收光谱、荧光光谱、傅里叶变换红外光谱和透射电子显微镜。进一步研究了荧光有机纳米颗粒的生物相容性评估及其细胞摄取行为，以评估其潜在的生物医学应用。结果表明，这些荧光有机纳米颗粒可以在室温空气气氛中获得，无需催化剂或引发剂。此外，这些基于交联聚集诱导发光染料的荧光有机纳米颗粒具有均匀的形态、强烈的红色荧光、高水分散性和优异的生物相容性，使其成为各种生物医学应用的有前途的候选材料。
