Malinowska B, Pietraszek M, Chabielska E, Buczko W
Department of Pharmacodynamics, School of Medicine, Białystok.
Acta Physiol Pol. 1989 Jul-Aug;40(4):356-62.
In normotensive rats the effect of different doses of propranolol (1.0, 5.0 and 10.0 mg/kg i.p.) and ketanserin (10.0 mg/kg p.o.) on mean blood pressure and heart rate and on cardiovascular response to noradrenaline (0.1, 0.3, 0.5, 0.7 and 1.0 micrograms/kg i.v.) was examined. The drugs were given separately or together. Propranolol slightly reduced the hypotensive effect of ketanserin. On the other hand a decrease in heart rate caused by propranolol was not affected by ketanserin. Our results show that propranolol given with ketanserin did not change the effect of the latter on the cardiovascular system.
在正常血压大鼠中，研究了不同剂量的普萘洛尔（腹腔注射1.0、5.0和10.0毫克/千克）和酮色林（口服10.0毫克/千克）对平均血压、心率以及对去甲肾上腺素（静脉注射0.1、0.3、0.5、0.7和1.0微克/千克）的心血管反应的影响。这些药物单独或联合给药。普萘洛尔略微降低了酮色林的降压作用。另一方面，普萘洛尔引起的心率下降不受酮色林影响。我们的结果表明，普萘洛尔与酮色林联合使用不会改变后者对心血管系统的作用。
