用于诊断呼吸道真菌感染的非分子方法。
Nonmolecular methods for the diagnosis of respiratory fungal infections.
作者信息
Lamoth Frédéric, Alexander Barbara D
机构信息
Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Box 102359, Durham, NC 27710, USA; Clinical Microbiology Laboratory, Department of Pathology, Duke University Medical Center, 108 Carl building, Durham, NC 27710, USA; Infectious Diseases Service and Institute of Microbiology, Lausanne University Hospital, Rue du Bugnon 46, 1011 Lausanne, Switzerland.
Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Box 102359, Durham, NC 27710, USA; Clinical Microbiology Laboratory, Department of Pathology, Duke University Medical Center, 108 Carl building, Durham, NC 27710, USA.
出版信息
Clin Lab Med. 2014 Jun;34(2):315-36. doi: 10.1016/j.cll.2014.02.006. Epub 2014 Apr 12.
Diagnosis of invasive fungal pneumonias by conventional culture methods is difficult to assess and often delayed. Nonmolecular fungal markers have emerged as an important adjunctive tool to support their diagnosis in combination with other clinical, radiologic, and microbiological criteria of invasive fungal diseases. Concerns about the sensitivity and specificity of some tests in different patient populations should lead to warnings about their widespread use. None can identify the emerging and particularly deadly fungal pathogens responsible for mucormycosis. The role of nonmolecular fungal markers should be better defined in combination with other microbiological and radiologic tools in preemptive antifungal strategies.
通过传统培养方法诊断侵袭性真菌性肺炎很难评估，而且往往会延迟。非分子真菌标志物已成为一种重要的辅助工具，可结合侵袭性真菌病的其他临床、放射学和微生物学标准来支持其诊断。对某些检测在不同患者群体中的敏感性和特异性的担忧，应引发对其广泛使用的警示。没有一种检测方法能够识别导致毛霉病的新出现且特别致命的真菌病原体。在抢先抗真菌策略中，应结合其他微生物学和放射学工具，更好地明确非分子真菌标志物的作用。
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