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呼吸道真菌感染:分子诊断测试

Respiratory fungal infections: molecular diagnostic tests.

作者信息

Hazen Kevin C

机构信息

Clinical Microbiology Laboratory, Department of Pathology, Duke University Health System, 2902 DUMC, 116 CARL Building, Durham, NC 27710, USA.

出版信息

Clin Lab Med. 2014 Jun;34(2):351-64. doi: 10.1016/j.cll.2014.02.008. Epub 2014 Apr 12.

Abstract

Fungal infection of the respiratory tract can take several forms, the most common of which is pneumonia. Fungal infection can occur in the immunocompetent typically as a result of inhalation of a large inoculum of fungal elements. However, the number of etiologic agents attacking immunocompetent individuals and causing significant infection is limited. Molecular assays are a potential additional and sensitive weapon that can be added to the diagnostic arsenal used by physicians to determine whether a fungus is definitively, probably, or possibly causing infection in a patient.

摘要

呼吸道真菌感染可表现为多种形式,其中最常见的是肺炎。真菌感染通常在免疫功能正常者中发生,多因吸入大量真菌成分接种物所致。然而,侵袭免疫功能正常个体并导致严重感染的病原体数量有限。分子检测是一种潜在的、可补充的敏感手段,可纳入医生的诊断工具库,以确定真菌是否确实、很可能或可能导致患者感染。

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