Hazen Kevin C
Clinical Microbiology Laboratory, Department of Pathology, Duke University Health System, 2902 DUMC, 116 CARL Building, Durham, NC 27710, USA.
Clin Lab Med. 2014 Jun;34(2):351-64. doi: 10.1016/j.cll.2014.02.008. Epub 2014 Apr 12.
Fungal infection of the respiratory tract can take several forms, the most common of which is pneumonia. Fungal infection can occur in the immunocompetent typically as a result of inhalation of a large inoculum of fungal elements. However, the number of etiologic agents attacking immunocompetent individuals and causing significant infection is limited. Molecular assays are a potential additional and sensitive weapon that can be added to the diagnostic arsenal used by physicians to determine whether a fungus is definitively, probably, or possibly causing infection in a patient.
呼吸道真菌感染可表现为多种形式,其中最常见的是肺炎。真菌感染通常在免疫功能正常者中发生,多因吸入大量真菌成分接种物所致。然而,侵袭免疫功能正常个体并导致严重感染的病原体数量有限。分子检测是一种潜在的、可补充的敏感手段,可纳入医生的诊断工具库,以确定真菌是否确实、很可能或可能导致患者感染。