干扰素-γ释放试验

Interferon-gamma release assays.

作者信息

Belknap Robert, Daley Charles L

机构信息

Denver Public Health Department, University of Colorado School of Medicine, 605 Bannock Street, Denver, CO 80204, USA.

National Jewish Health, University of Colorado School of Medicine, 1400 Jackson Street, Denver, CO 80206, USA.

出版信息

Clin Lab Med. 2014 Jun;34(2):337-49. doi: 10.1016/j.cll.2014.02.007. Epub 2014 Apr 12.

DOI:10.1016/j.cll.2014.02.007

PMID:24856531

Abstract

Diagnosis of latent tuberculosis infection (LTBI) should be targeted toward individuals and groups with high risk of progression to active tuberculosis (TB). Low-risk populations should not be screened. Interferon-gamma release assays (IGRAs) perform as well or better than the tuberculin skin test in most targeted populations. IGRAs are preferred for bacille Calmette-Guérin (BCG)-vaccinated populations. A positive IGRA in a person at low risk for TB exposure should be confirmed with a repeat test or another method before recommending LTBI treatment. The choice of which IGRA to use is generally based on the costs and feasibility of performing the test.

摘要

潜伏性结核感染（LTBI）的诊断应针对有进展为活动性结核病（TB）高风险的个体和群体。低风险人群不应进行筛查。在大多数目标人群中，干扰素-γ释放试验（IGRAs）的表现与结核菌素皮肤试验相当或更好。对于接种卡介苗（BCG）的人群，IGRAs是首选。在建议进行LTBI治疗之前，对于结核病暴露风险低的人，其IGRA结果呈阳性应通过重复检测或其他方法进行确认。选择使用哪种IGRA通常基于进行检测的成本和可行性。