Wang Dian, Abrams Ross A
From the Department of Radiation Oncology, Rush University Medical Center, Chicago, IL.
Am Soc Clin Oncol Educ Book. 2014:244-51. doi: 10.14694/EdBook_AM.2014.34.244.
Radiotherapy for soft tissue sarcoma (STS) has advanced significantly over the past 50 years. This review focuses briefly on the period from 1964 to 1999 and more substantially on the changes of the past 15 years, such as IMRT and image-guided radiotherapy (IG-RT), especially when brought together (IG-IMRT) in the same planning and delivery process to treat localized STS. In particular, the introduction of IG-RT, target volume definitions for IG-RT, and review of recent clinical trials using IG-RT to treat localized STS in extremity will be reviewed. Finally, potential investigational agents combined with IG-RT to improve outcomes in patients with localized STS are discussed.
在过去50年中，软组织肉瘤（STS）的放射治疗取得了显著进展。本综述简要聚焦于1964年至1999年期间，更着重于过去15年的变化，如调强放疗（IMRT）和图像引导放疗（IG-RT），特别是当它们在同一计划和实施过程中结合使用（IG-IMRT）来治疗局限性STS时。尤其将对IG-RT的引入、IG-RT的靶区定义以及近期使用IG-RT治疗肢体局限性STS的临床试验进行综述。最后，将讨论与IG-RT联合使用以改善局限性STS患者治疗效果的潜在研究药物。
