Kiyatkin E A
Department of Neuropharmacology, USSR Academy of Medical Sciences, Moscow.
Int J Neurosci. 1989 Jan;44(1-2):91-110. doi: 10.3109/00207458908986187.
To study the regulation of nociceptive sensitivity/behavioral reactivity in animals during aversive states of different nature, the changes of vocalization thresholds and tail-withdrawal latencies were investigated in rats in free behavior, during restraint stress, after acute trauma to an extremity and under intraperitoneal acetic acid administration. To understand opioid peptide involvement in mediation of the changes obtained, this analysis was also done during opiate receptor blockade by naloxone. The data on the modification of vocalization and movement reactivity as well as on the changes of suprarenal weight and gastric ulceration, produced in normal and naloxone-treated rats by innoxious stressogenic, noxious somatic and visceral stimulation are discussed in relation with: 1. the peculiarities of sensitivity and responsivity of animals to external stimuli in aversive environment; 2. the role of these changes in maintenance of an animal's adaptive activity produced by environmental threat and their mediation by endogenous opioids; 3. the functional significance of the activation of endogenous opioidergic neurotransmission in organization, realization and modification of an animal's adaptive activity, directed on behavioral escape from aversive environment as well as on satisfaction of actual biological and zoosocial needs, in regulation of precise conformity among homeostasis, behavior and variable environment.
为研究动物在不同性质厌恶状态下伤害性感受敏感性/行为反应性的调节，我们在自由行为的大鼠、束缚应激期间、肢体急性创伤后以及腹腔注射醋酸后，研究了发声阈值和甩尾潜伏期的变化。为了解阿片肽是否参与介导这些变化，在纳洛酮阻断阿片受体期间也进行了此项分析。本文讨论了在正常大鼠和经纳洛酮处理的大鼠中，无害应激源、有害躯体刺激和内脏刺激所产生的发声和运动反应性改变以及肾上腺重量和胃溃疡变化的数据，并涉及以下方面：1. 动物在厌恶环境中对外部刺激的敏感性和反应性特点；2. 这些变化在维持环境威胁所产生的动物适应性活动中的作用以及内源性阿片肽对其的介导作用；3. 内源性阿片能神经传递的激活在动物适应性活动的组织、实现和改变中的功能意义，这种适应性活动旨在通过行为逃离厌恶环境以及满足实际的生物和社会需求，从而调节内环境稳定、行为和变化环境之间的精确一致性。
