Tizabi Y, Gilad V H, Gilad G M
Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059.
Neurosci Lett. 1989 Oct 23;105(1-2):177-82. doi: 10.1016/0304-3940(89)90033-5.
The effects of prolonged (2 months) corticosterone (CORT) treatment on several cholinergic markers of various brain areas were compared to the effects of prolonged intermittent exposure to stress. CORT, but not stress, caused a significant reduction in the number of acetylcholinesterase-stained neurons in the medial septal area. Neither treatment resulted in any hippocampal pyramidal cell loss. It is concluded that a time-dependent degeneration of the septohippocampal cholinergic system follows 2 months of CORT administration but not chronic intermittent stress of this duration.
将长期（2个月）皮质酮（CORT）治疗对不同脑区几种胆碱能标志物的影响与长期间歇性应激的影响进行了比较。CORT而非应激导致内侧隔区乙酰胆碱酯酶染色神经元数量显著减少。两种治疗均未导致任何海马锥体细胞丢失。结论是，给予2个月的CORT后，隔海马胆碱能系统会出现时间依赖性退化，但这种持续时间的慢性间歇性应激不会导致该系统退化。
