Sechser T, Petrásek R, Stika L, Modr Z, Elis J, Malý J
Institute for Clinical and Experimental Medicine, Prague, Czechoslovakia.
Pol J Pharmacol Pharm. 1989 Nov-Dec;41(6):527-32.
In Czechoslovakia, drug utilization studies showed that oral forms of digoxin and lanatoside C are traditionally the most prescribed cardiac glycosides. Our study of the relative bioavailability of the oral form of lanatoside C revealed that the drug has a low and irregular bioavailability making use of this frequently prescribed drug non-rational. The above data definitely contributed to a sharp decrease in the use of the oral form of lanatoside C in our country, which is in agreement with consumption trends in other European countries. However, the use of only drug forms with a good bioavailability is one aspect of new approaches applied in pharmacotherapy with cardiac glycosides resulting in gradual decrease of their consumption as a pharmacological group. Clinical pharmacological evaluation of individual drug forms and postgraduate education in clinical pharmacology of cardiac glycosides contribute significantly--apart from other regulatory measures--to a more rational use of cardiac glycosides in Czechoslovakia.
在捷克斯洛伐克，药物利用研究表明，地高辛和毛花苷C的口服制剂传统上是处方量最大的强心苷类药物。我们对毛花苷C口服制剂相对生物利用度的研究显示，该药物生物利用度低且不规则，这使得频繁使用这种药物变得不合理。上述数据无疑导致了我国毛花苷C口服制剂使用量的急剧下降，这与其他欧洲国家的消费趋势一致。然而，仅使用生物利用度良好的药物剂型只是强心苷类药物药物治疗新方法的一个方面，这导致了强心苷类药物作为一个药理学类别其消耗量逐渐减少。除其他监管措施外，对个别药物剂型的临床药理学评估以及强心苷类药物临床药理学的研究生教育对捷克斯洛伐克更合理地使用强心苷类药物做出了重大贡献。
