针对空间工作记忆的多次重复经颅磁刺激：两个皮质区域的比较研究
Multiple bout rTMS on spatial working memory: a comparison study of two cortical areas.
作者信息
Pearce Alan J, Lum Jarrad A G, Seth Sunaina, Rafael Olivia, Hsu Chia-Ming K, Drury Hannah G K, Tooley Gregory A
机构信息
Cognitive and Neuroscience Unit, Centre for Mental Health and Wellbeing, School of Psychology, Deakin University, Melbourne, Australia.
Cognitive and Neuroscience Unit, Centre for Mental Health and Wellbeing, School of Psychology, Deakin University, Melbourne, Australia.
出版信息
Biol Psychol. 2014 Jul;100:56-9. doi: 10.1016/j.biopsycho.2014.05.002. Epub 2014 May 21.
It has been established that acute (within-session) repetitive transcranial magnetic stimulation (rTMS) improves spatial working memory (SWM). However, questions remain regarding the safety and effectiveness of multiple bouts of rTMS and the optimal cortical area to stimulate. This preliminary study investigated, in healthy participants, multiple bouts of rTMS over the dorsolateral pre-frontal cortex (DLPFC), or posterior parietal cortex (PPC) on SWM. Twenty participants (10m, 10f), all naïve to rTMS, where randomized into a DLPFC or PPC group, receiving six sessions of rTMS (5Hz at 80% of motor threshold) every second day over two weeks. Prior to and post rTMS bouts, all participants completed testing for SWM measuring individuals' accuracy, strategy, and speed. Following repeated bouts of rTMS, significant improvements were observed with no contraindications in stimulating PPC but not DLPFC. This preliminary study has demonstrated that repeated rTMS bouts improve SWM safety providing potential for clinical application.
已经证实，急性（单次治疗期间）重复经颅磁刺激（rTMS）可改善空间工作记忆（SWM）。然而，关于多次重复rTMS的安全性和有效性以及最佳刺激皮层区域仍存在疑问。这项初步研究在健康参与者中调查了对背外侧前额叶皮层（DLPFC）或顶叶后皮层（PPC）进行多次重复rTMS对SWM的影响。20名参与者（10名男性，10名女性），均未接受过rTMS治疗，被随机分为DLPFC组或PPC组，在两周内每隔一天接受六次rTMS治疗（5Hz，运动阈值的80%）。在rTMS治疗前后，所有参与者都完成了SWM测试，测量个体的准确性、策略和速度。在多次重复rTMS治疗后，观察到显著改善，刺激PPC时无禁忌症，但刺激DLPFC时则不然。这项初步研究表明，重复rTMS治疗可安全改善SWM，具有临床应用潜力。
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