Fujise O, Miura M, Hamachi T, Aida Y, Nishimura F
Section of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Aust Dent J. 2014 Jun;59(2):245-51. doi: 10.1111/adj.12177.
Azithromycin is an antibiotic belonging to the macrolides. Previous case reports showed that azithromycin has a regenerative effect on periodontal tissue in addition to improving periodontal gingival inflammation. Recently, we experienced three periodontitis cases, all of which showed severe bone loss. However, their gingival inflammatory signs differed greatly. The present case reports evaluated the regenerative effects of azithromycin on periodontitis sites with different clinical signs of gingival inflammation.
In Case 1, generalized chronic periodontitis with severe gingival inflammation was treated with azithromycin before periodontal treatment. In contrast, Case 2 presented with few clinical signs of gingival inflammation, but was treated with azithromycin prescribed within a day of scaling and root planing. In Case 3, teeth with moderate gingival inflammation were treated with azithromycin after a series of scaling and root planing.
Remarkable alveolar bone growth, regardless of baseline gingival inflammation, was noted in all three cases.
The use of adjunctive azithromycin in scaling and root planing may be effective for periodontal tissue regeneration. This property may be independent of the degree of baseline gingival inflammation.
阿奇霉素是一种大环内酯类抗生素。既往病例报告显示，阿奇霉素除了能改善牙周牙龈炎症外，对牙周组织还有再生作用。最近，我们遇到了3例牙周炎患者，均表现出严重的骨质流失。然而，他们的牙龈炎症体征差异很大。本病例报告评估了阿奇霉素对具有不同牙龈炎症临床体征的牙周炎部位的再生作用。
病例1为广泛性慢性牙周炎伴严重牙龈炎症，在进行牙周治疗前先用阿奇霉素治疗。相比之下，病例2几乎没有牙龈炎症的临床体征，但在龈上洁治和根面平整治疗当天内就开具了阿奇霉素处方。病例3的牙齿有中度牙龈炎症，在进行一系列龈上洁治和根面平整治疗后用阿奇霉素治疗。
在所有3例病例中均观察到，无论基线牙龈炎症情况如何，牙槽骨均有显著生长。
在龈上洁治和根面平整治疗中辅助使用阿奇霉素可能对牙周组织再生有效。这种特性可能与基线牙龈炎症的程度无关。
