Bennett M H, Lunsford L D, Akin O, Martinez A J
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pa.
Stereotact Funct Neurosurg. 1989;53(4):247-60. doi: 10.1159/000099540.
Spinal cord evoked potentials (SCEP) in response to epispinal stimulation were measured in an experimental animal model designed to define further the value of electrophysiological monitoring during dorsal root entry zone (DREZ) surgery. Thirteen cats underwent microsurgical stereotactic thermal radiofrequency lesions of the DREZ. The postmortem histological examination of the location and extent of the lesions were compared with the intraoperative electrophysiological and postoperative neurological effects. Despite the use of the stereotactic microsurgical technique, the sizes and the configurations of the DREZ lesions varied greatly. Changes in ascending and descending SCEP correlated highly with the extent of the histologically defined injury to the dorsal and lateral columns. SCEP monitoring during experimental DREZ surgery provided a sensitive indication of lesion invasion into the dorsal or lateral columns. The high degree of correlation between changes in descending SCEP and extension of the surgical lesion into the lateral column indicates that the SCEP technique is more sensitive than somatosensory cortical evoked potentials in the intraoperative electrophysiological assessment of corticospinal tract function, and it may prove to be a useful surgical adjunct during DREZ surgery in humans.
在一个旨在进一步明确背根入髓区（DREZ）手术期间电生理监测价值的实验动物模型中，测量了对脊髓表面刺激的脊髓诱发电位（SCEP）。13只猫接受了DREZ的显微外科立体定向热射频损伤。将损伤的位置和范围的死后组织学检查结果与术中电生理效应和术后神经学效应进行了比较。尽管使用了立体定向显微外科技术，但DREZ损伤的大小和形态差异很大。上行和下行SCEP的变化与组织学确定的背柱和外侧柱损伤程度高度相关。实验性DREZ手术期间的SCEP监测为损伤侵入背柱或外侧柱提供了敏感指标。下行SCEP变化与手术损伤延伸至外侧柱之间的高度相关性表明，在术中对皮质脊髓束功能进行电生理评估时，SCEP技术比体感皮层诱发电位更敏感，并且它可能被证明是人类DREZ手术期间一种有用的手术辅助手段。
