两名患者的汗孔角化症伴鳞状细胞癌。

Squamous cell carcinoma in porokeratosis in two patients.

作者信息

O'Neill A, Commens C A, Kossard S, Coats H

机构信息

Skin and Cancer Foundation, Darlinghurst, NSW.

出版信息

Australas J Dermatol. 1989;30(2):77-80. doi: 10.1111/j.1440-0960.1989.tb00423.x.

DOI:10.1111/j.1440-0960.1989.tb00423.x

PMID:2486176

Abstract

Malignancy arising in porokeratoses is a well recognised but infrequently reported complication. Histological studies suggest that malignancy arises from the abnormal clone of keratinocytes which produce the cornoid lamella. We report two cases of squamous cell carcinoma arising in porokeratoses and postulate genetic, environmental and host factors as important in the evolution of their malignancy.

摘要

汗孔角化症中发生的恶性肿瘤是一种公认但鲜有报道的并发症。组织学研究表明，恶性肿瘤起源于产生鸡眼样板的角质形成细胞异常克隆。我们报告了两例汗孔角化症中发生的鳞状细胞癌病例，并推测遗传、环境和宿主因素在其恶性肿瘤的演变中起重要作用。