Weitz Ilene Ceil
Associate Clinical Professor of Medicine, Jane Anne Nohl Division of Hematology, Keck- USC School of Medicine, Los Angeles, CA , United States.
Thromb Res. 2014 May;133 Suppl 2:S117-21. doi: 10.1016/S0049-3848(14)50020-5.
The complement system is important part of our innate immune system and interacts directly with the hemostatic system. Disorders of complement activation or dysregulation resulting in excess complement generation, such as Paroxysmal Nocturnal Hemoglobinuria (PNH), atypical Hemolytic uremic Syndrome (aHUS) and antiphospholipid syndrome (APLS) have been associated with significant thrombophilia. Terminal Complement (C5b-9) deposition on endothelial and tumor cell membranes has also been reported in a variety of cancer. Recent developments in complement inhibition have given us new insights into the mechanism of thrombosis in these disorders.
补体系统是我们先天免疫系统的重要组成部分，并且直接与止血系统相互作用。补体激活紊乱或失调导致补体生成过多，如阵发性夜间血红蛋白尿（PNH）、非典型溶血性尿毒症综合征（aHUS）和抗磷脂综合征（APLS），均与显著的血栓形成倾向有关。在多种癌症中也报道了终末补体（C5b-9）在内皮细胞膜和肿瘤细胞膜上的沉积。补体抑制方面的最新进展让我们对这些疾病中血栓形成的机制有了新的认识。
