巴西骨质疏松症患者的乳糜泻筛查。
Celiac disease screening in Brazilian patients with osteoporosis.
作者信息
Gusso Luiza, Simões Mariana Cionek, Skare Thelma L, Nisihara Renato, Burkiewicz Claudine C, Utiyama Shirley
机构信息
Rheumatology Unit, Hospital Universitário Evangélico de Curitiba, Curitiba, PR, Brazil.
Universidade Positivo, Curitiba, PR, Brazil.
出版信息
Arq Bras Endocrinol Metabol. 2014 Apr;58(3):270-3. doi: 10.1590/0004-2730000002919.
OBJECTIVE
To analyze if it is worthwhile to screen Brazilian osteoporotic patients for celiac disease (CD).
SUBJECTS AND METHODS
One hundred patients with osteoporosis and 97 controls were evaluated for IgA-EmA (IgA anti-endomysial antibodies) by indirect immunofluorescence method and IgG-anti-tTG (tissue transglutaminase) by ELISA assay. Positive patients were invited to have gastrointestinal endoscopy with jejunal biopsy.
RESULTS
Two patients had positive IgG-anti-tTG test and one of them also showed positive IgA-EmA. Only the latter had a positive duodenal biopsy for CD. None of the controls were positive for either auto-antibodies.
CONCLUSION
We observed low prevalence of CD in osteoporotic Brazilian patients. This finding does not support routine screening for CD in patients with osteoporosis in our geographic region.
目的
分析对巴西骨质疏松患者进行乳糜泻（CD）筛查是否值得。
对象与方法
采用间接免疫荧光法对100例骨质疏松患者和97例对照者进行IgA-EmA（IgA抗肌内膜抗体）检测，采用酶联免疫吸附测定法检测IgG-抗tTG（组织转谷氨酰胺酶）。邀请检测呈阳性的患者进行胃肠内镜检查及空肠活检。
结果
2例患者IgG-抗tTG检测呈阳性，其中1例IgA-EmA也呈阳性。仅后者十二指肠活检显示CD阳性。对照者中两种自身抗体均无阳性。
结论
我们观察到巴西骨质疏松患者中CD的患病率较低。这一发现不支持在我们所在地理区域对骨质疏松患者进行CD的常规筛查。
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