Huang Lu, Fozo Elizabeth M, Zhang Tao, Liaw Peter K, He Wei
Department of Materials Science and Engineering, The University of Tennessee, Knoxville, TN 37996-2100, USA.
Department of Microbiology, The University of Tennessee, Knoxville, TN 37996-0845, USA.
Mater Sci Eng C Mater Biol Appl. 2014 Jun 1;39:325-9. doi: 10.1016/j.msec.2014.03.017. Epub 2014 Mar 12.
The antimicrobial behavior of Cu-bearing Zr-based bulk metallic glasses (BMGs) was investigated for the first time against the Gram positive bacterium Staphylococcus aureus to evaluate their potential applications in healthcare settings. Despite their lack of bacteria-killing effect under a relatively severe experimental setting of dynamic immersion, the biocidal potency of the two Zr-based BMGs was demonstrated via a moist contact assay. There was a significant reduction in viable bacterial populations after 4h of contact on the Zr-based BMGs, which was evidenced by the pronounced reduction in viable bacterial populations. To understand the mechanism of cell death, a direct relationship was established between the killing efficiency and the ability of the substrate to release Cu ions. Findings in this study will direct the future design of antimicrobial BMGs with enhanced killing efficacy.
首次研究了含铜锆基块状金属玻璃（BMG）对革兰氏阳性细菌金黄色葡萄球菌的抗菌行为，以评估其在医疗环境中的潜在应用。尽管在相对严苛的动态浸泡实验条件下它们缺乏杀菌效果，但通过湿接触试验证明了两种锆基BMG的杀菌效力。在锆基BMG上接触4小时后，活菌数量显著减少，这一点可通过活菌数量的明显减少得到证明。为了理解细胞死亡机制，在杀菌效率与底物释放铜离子的能力之间建立了直接关系。本研究的结果将指导未来设计具有更高杀菌效力的抗菌BMG。
