The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.
Department of Physiology, Georgia Regents University, Augusta, GA 30912, USA.
Chin J Nat Med. 2014 Apr;12(4):266-72. doi: 10.1016/S1875-5364(14)60053-4.
In traditional Chinese medicine, Nitraria sibirica Pall. (Nitrariaceae) is used to treat hypertension. This study determined the effects of the total alkaloids of the leaves of Nitraria sibirica (NSTA) on blood pressure and albuminuria in mice treated with angiotensin II and a high-salt diet (ANG/HS). Adult mice were divided into three groups: control; infused with angiotensin II and fed a diet containing 4% NaCl (ANG/HS; and ANG/HS plus injection of NSTA (1 mg·kg(-1)·d(-1), i.p.). After treatment of these regimens, daily water and food intake, kidney weight, blood pressure, urinary albumin excretion, renal concentrations of inflammatory markers, including soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1), and the expression of renal fibrosis markers were determined. Compared to the control group, the ANG/HS group had higher blood pressure and urinary albumin excretion. Treatment with NSTA in ANG/HS mice for three weeks significantly reduced blood pressure and urinary albumin excretion. ANG/HS treatment caused elevated levels of sICAM-1 and MCP-1, as well as increased fibrosis markers. Concurrent treatment with ANG/HS and NSTA attenuated the levels and expression of renal inflammatory and fibrosis markers. Treatment with NSTA effectively reduces hypertension-induced albuminuria through the reduction of renal inflammatory and fibrosis markers.
在中医中，西伯利亚滨藜（滨藜科）用于治疗高血压。本研究旨在确定西伯利亚滨藜叶总生物碱（NSTA）对血管紧张素 II 和高盐饮食（ANG/HS）治疗的小鼠血压和蛋白尿的影响。成年小鼠分为三组：对照组；输注血管紧张素 II 并喂食含 4%NaCl 的饮食（ANG/HS）；和 ANG/HS 加 NSTA 注射（1mg·kg(-1)·d(-1)，腹腔注射）。在这些方案治疗后，测定每日水和食物摄入量、肾脏重量、血压、尿白蛋白排泄、肾脏炎症标志物浓度，包括可溶性细胞间黏附分子-1（sICAM-1）和单核细胞趋化蛋白-1（MCP-1），以及肾纤维化标志物的表达。与对照组相比，ANG/HS 组血压和尿白蛋白排泄更高。用 NSTA 治疗 ANG/HS 小鼠 3 周可显著降低血压和尿白蛋白排泄。ANG/HS 处理导致 sICAM-1 和 MCP-1 水平升高，纤维化标志物增加。ANG/HS 和 NSTA 同时治疗可减轻肾炎症和纤维化标志物的水平和表达。用 NSTA 治疗可通过降低肾炎症和纤维化标志物有效减轻高血压引起的蛋白尿。
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