Henderson R A
Department of Cardiology, Guy's Hospital, London.
Br Heart J. 1989 Nov;62(5):411-4. doi: 10.1136/hrt.62.5.411.
The Randomised Intervention Treatment of Angina (RITA) Trial is a prospective, randomised study to compare the short term and long term effects of percutaneous transluminal coronary angioplasty and coronary artery bypass surgery. During the study a register of patients undergoing coronary arteriography at the fourteen participating centres is being maintained to assess the overall context of patient recruitment. Patients with arteriographically proven coronary artery disease are considered for the trial if the participating cardiologist and surgeon agree that equivalent revascularisation could be achieved by either treatment method. Patients who satisfy the trial entry criteria are randomised to treatment by coronary angioplasty or coronary artery bypass surgery, with prospective stratification into groups with one, two, or three treatment vessels. Randomisation implies an intention to treat the patient by the assigned procedure and the analysis of long term results will include all randomised cases. The trial will recruit at least 1000 patients who will be followed for five years. The major trial end points include death, new myocardial infarction, and new coronary angioplasty or coronary artery bypass procedures. Other outcome measures include symptom and employment status, quality of life, exercise tolerance, and left ventricular function.
心绞痛随机干预治疗（RITA）试验是一项前瞻性随机研究，旨在比较经皮腔内冠状动脉成形术和冠状动脉旁路移植术的短期和长期效果。在研究期间，十四个参与中心正在维护一份接受冠状动脉造影患者的登记册，以评估患者招募的整体情况。如果参与的心脏病专家和外科医生认为两种治疗方法均可实现等效的血运重建，则考虑将冠状动脉造影证实患有冠状动脉疾病的患者纳入试验。符合试验入选标准的患者被随机分配接受冠状动脉成形术或冠状动脉旁路移植术治疗，并前瞻性分层为有一、二或三支治疗血管的组。随机化意味着有意按照指定程序治疗患者，长期结果分析将包括所有随机病例。该试验将招募至少1000名患者，并对其进行为期五年的随访。主要试验终点包括死亡、新发心肌梗死以及新的冠状动脉成形术或冠状动脉旁路移植手术。其他结局指标包括症状和就业状况、生活质量、运动耐量和左心室功能。
