Department of Emergency and Organs Transplantation, University of Bari, Policlinico di Bari, P.zza Giulio Cesare 11, Bari, Italy.
Department of Emergency and Organs Transplantation, University of Bari, Policlinico di Bari, P.zza Giulio Cesare 11, Bari, Italy.
Int J Surg. 2014;12 Suppl 1:S98-102. doi: 10.1016/j.ijsu.2014.05.041. Epub 2014 May 24.
The diagnosis of incidental thyroid carcinoma in patients submitted to thyroidectomy for a benign disease is quite frequent. A retrospective analysis was performed on 455 patients submitted to surgical intervention in order to establish the incidence of this kind of carcinoma. Two hundred fifty-six patients (56%) were affected by benign disease (176 multinodular goiter, 12 uninodular goiter, 1 Plummer disease and 67 Basedow disease) and 202 (44%) by carcinoma. In 28 of 256 patients (11%), affected by benign disease, occurred a histological diagnosis of thyroid carcinoma, (10 papillary carcinoma, 1 follicular carcinoma, 29 papillary carcinoma follicular variant). In this study it's considered incidental thyroid carcinoma the one occurred in patients who never underwent Fine Needle Aspiration (FNA) and there were no suspicious features in all exams that may suggest the presence of carcinoma. Twenty-three of the 40 incidental carcinoma (57.5%) were microcarcinomas. Ten patients had a sincronous carcinoma. Actually, these patients are still in a follow up program and no recurrency of disease is occasionally observed. This study shows that the only way to put doubts on the real benignity of the disease is the fine needle aspiration; there are no other instruments that could identify the occurrence of the carcinoma. Moreover in the majority of cases the incidental carcinoma is a microcarcinoma, it doesn't reach significant volume, may be not centered by a FNA, but in most cases it's not really biologically aggressive.
在因良性疾病接受甲状腺切除术的患者中,偶然诊断出甲状腺癌的情况相当常见。对 455 名接受手术干预的患者进行了回顾性分析,以确定这种癌的发生率。256 名患者(56%)患有良性疾病(176 例多结节性甲状腺肿、12 例单结节性甲状腺肿、1 例 Plummer 病和 67 例 Basedow 病),202 名患者患有癌。在 256 名患有良性疾病的患者中,有 28 例(11%)发生了甲状腺癌的组织学诊断,包括 10 例乳头状癌、1 例滤泡状癌、29 例滤泡状癌变异型。在这项研究中,偶然甲状腺癌是指从未接受过细针穿刺(FNA)且所有检查均无提示癌存在的可疑特征的患者中发生的癌。在 40 例偶然癌中,有 23 例(57.5%)为微癌。10 例患者同时患有癌。实际上,这些患者仍在随访计划中,偶尔观察不到疾病复发。本研究表明,唯一能对疾病的真正良性性质产生怀疑的方法是细针穿刺;没有其他仪器可以识别癌的发生。此外,在大多数情况下,偶然癌是微癌,它不会达到显著的体积,可能不会被 FNA 所累及,但在大多数情况下,它并不是真正具有侵袭性的。