Montagnini Bruno Garcia, Silva Luiza Sienna, dos Santos Alice Hartmann, Anselmo-Franci Janete Aparecida, Fernandes Glaura Scantamburlo Alves, Mesquita Suzana de Fátima Paccola, Gerardin Daniela Cristina Ceccatto
Department of Physiological Sciences, State University of Londrina, 86051-980 Londrina, Paraná, Brazil.
Department of Morphology, Estomatology and Physiology, University of São Paulo, 14040-900 Ribeirão Preto, São Paulo, Brazil.
Physiol Behav. 2014 Jun 22;133:122-9. doi: 10.1016/j.physbeh.2014.05.016. Epub 2014 May 24.
Methylphenidate (MPH) is a psychostimulant drug which acts by blocking the dopamine and norepinephrine transporters and is the main drug used to treat attention deficit hyperactivity disorder in children and adolescents. During puberty, changes in neurotransmitter systems (including dopaminergic system) are engaged on the release of gonadal hormones and the development of cephalic structures responsible for reproductive function. This study investigated the effects of repeated treatment with methylphenidate during development on reproductive parameters of adult male rats. Wistar rats received MPH 2.5 mg/kg, MPH 5.0 mg/kg, or distilled water (gavage) from postnatal day (PND) 21 to PND 60. At PND 100, an increase in percentage of abnormal tail morphology sperm in MPH 2.5 and increase in testicular interstitial tissue volume in MPH groups as well as in the number of type A spermatogonia in MPH 5.0 group were observed. This study demonstrated that repeated administration of methylphenidate during periods corresponding childhood to early adulthood interfered on testicular function in rats at adult life.
哌甲酯（MPH）是一种精神振奋药物，其作用机制是阻断多巴胺和去甲肾上腺素转运体，是治疗儿童和青少年注意力缺陷多动障碍的主要药物。在青春期，神经递质系统（包括多巴胺能系统）的变化与性腺激素的释放以及负责生殖功能的头部结构的发育有关。本研究调查了发育期反复给予哌甲酯对成年雄性大鼠生殖参数的影响。从出生后第21天（PND）至第60天，Wistar大鼠接受2.5mg/kg、5.0mg/kg的MPH或蒸馏水（灌胃）。在PND 100时，观察到2.5mg/kg MPH组异常尾部形态精子百分比增加，MPH各剂量组睾丸间质组织体积增加，5.0mg/kg MPH组A型精原细胞数量增加。本研究表明，在相当于儿童期至成年早期的时间段内反复给予哌甲酯会干扰成年大鼠的睾丸功能。
