Sienra Pérez J C, Cardoso Saldaña G, Ramírez Campos B, Ahumada Ayala M, Posadas Romero C
Instituto Nacional de Cardiología Ignacio Chávez.
Arch Inst Cardiol Mex. 1989 Jan-Feb;59(1):35-42.
Cardiovascular disease (CVD) constitutes the main cause of death in diabetes mellitus (DM): Previous studies at the "Instituto Nacional de Cardiología de México" have investigated the metabolic alterations of survivors of a myocardial infarction (MI), but none of them had focused on the metabolic profile of the diabetic patient. We compared two groups of patients with ischemic heart disease (IHD), one with (DMG) and one without (NDMG) Diabetes Mellitus, to investigate differences in the prevalence and nature of hyperlipoproteinemias (HLP) and other risk factors of atherosclerosis. DMG consisted of 117 patients (75 male, 42 female) and NDMG consisted of 119 patients (91 male y 28 female). (Female NDMG vs female DMG p less than 0.05). The presence of risks factors of atherosclerosis was investigated in all patients, and total cholesterol (chol) triglycerides (TG) and glucose were measured in post-absorptive phase. There were no differences regarding mean age (DMG: 60 +/- 8 years, NDM: 60 +/- 11 years), Quetelet Index (Kg./mt2: DMG: 26.5 +/- 3, NDMG: 26.7 +/- 3), TG: (DMG: 246.2 +/- 125, NDMG: 223.5 +/- 129) or Chol (DMG: 216 +/- 42 mg/dl, NDMG: 225 +/- 45 mg/dl). Hypertriglyceridemia was significantly higher in patients with DM, as a whole and when both sexes were studied separately (p less than 0.05). Hypercholesterolemia was significantly higher in NDMG (p less than 0.05) and without significance, in diabetic women. (p less than 0.05). Type IV phenotype was higher in DMG (p less than 0.05) whereas phenotypes IIa and IIa + IIb were more prevalent among non-diabetics (p less than 0.001, p less than 0.0001, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
心血管疾病（CVD）是糖尿病（DM）患者的主要死因：墨西哥国家心脏病研究所此前的研究调查了心肌梗死（MI）幸存者的代谢改变，但均未聚焦于糖尿病患者的代谢特征。我们比较了两组缺血性心脏病（IHD）患者，一组患有糖尿病（DMG），另一组未患糖尿病（NDMG），以研究高脂蛋白血症（HLP）的患病率和性质差异以及动脉粥样硬化的其他危险因素。DMG组有117例患者（75例男性，42例女性），NDMG组有119例患者（91例男性和28例女性）。（女性NDMG组与女性DMG组相比，p<0.05）。对所有患者进行动脉粥样硬化危险因素调查，并在吸收后阶段测量总胆固醇（chol）、甘油三酯（TG）和血糖。两组患者的平均年龄（DMG组：60±8岁，NDM组：60±11岁）、体重指数（kg/m²：DMG组：26.5±3，NDMG组：26.7±3）、TG（DMG组：246.2±125，NDMG组：223.5±129）或Chol（DMG组：216±42mg/dl，NDMG组：225±45mg/dl）无差异。总体而言，糖尿病患者的高甘油三酯血症显著更高，男女分别研究时也是如此（p<0.05）。NDMG组的高胆固醇血症显著更高（p<0.05），而糖尿病女性患者的高胆固醇血症无显著差异（p<0.05）。DMG组IV型表型更高（p<0.05），而IIa型和IIa+IIb型表型在非糖尿病患者中更常见（分别为p<0.001，p<0.0001）。（摘要截断于250字）
