Crowgey Theresa, Peters Katherine B, Hornsby Whitney E, Lane Amy, McSherry Frances, Herndon James E, West Miranda J, Williams Christina L, Jones Lee W
a Duke University Medical Center, Durham, NC 27710, USA.
Appl Physiol Nutr Metab. 2014 Jun;39(6):724-9. doi: 10.1139/apnm-2013-0380. Epub 2013 Dec 3.
The purpose of this study was to examine the relationship between self-reported exercise behavior, cardiorespiratory fitness (CRF), and cognitive function in early breast cancer patients. Thirty-seven breast cancer patients following completion of chemotherapy (median 16 months) and 14 controls were studied. Cognitive function was assessed using the Central Nervous System (CNS) Vital Signs software (CNS Vital Signs, LLC, Morrisville, N.C., USA), a computerized test battery consisting of 9 cognitive subtests. Exercise behavior was evaluated using the Godin Leisure Time Exercise Questionnaire, and CRF was assessed via a cardiopulmonary exercise test to assess peak oxygen consumption. Patients' mean total exercise was 184 ± 141 min·week(-1) compared with 442 ± 315 min·week(-1) in controls (p < 0.001). Significantly fewer patients (32%) were meeting exercise guidelines (i.e., ≥150 min of moderate-intensity or vigorous exercise per week) compared with 57% of controls (p = 0.014). Patients' peak oxygen consumption averaged 23.5 ± 6.3 mL·kg(-1)·min(-1) compared with 30.6 ± 7.0 mL·kg(-1)·min(-1) in controls (p < 0.01). Scores on the cognitive subdomains were generally lower in patients compared with controls, although only the difference in verbal memory was significant (unadjusted p = 0.041). In patients, weak to moderate correlations were indicated between exercise, peak oxygen consumption, and the majority of cognitive subdomain scores; however, there was a significant positive correlation between exercise and visual memory (r = 0.47, p = 0.004). In conclusion, breast cancer patients following the completion of primary adjuvant chemotherapy exhibit, in general, worse cognitive performance than healthy women from the general population, and such performance may be related to their level of exercise behavior.
本研究的目的是探讨早期乳腺癌患者自我报告的运动行为、心肺适能（CRF）与认知功能之间的关系。研究对象为37例完成化疗（中位时间16个月）的乳腺癌患者和14名对照者。使用中枢神经系统（CNS）生命体征软件（美国北卡罗来纳州莫里斯维尔市的CNS Vital Signs有限责任公司）评估认知功能，该软件是一个由9个认知子测试组成的计算机化测试组合。使用戈丁休闲时间运动问卷评估运动行为，并通过心肺运动测试评估CRF以测定峰值耗氧量。患者的平均总运动时间为184±141分钟·周⁻¹，而对照组为442±315分钟·周⁻¹（p<0.001）。与57%的对照组相比，达到运动指南（即每周进行≥150分钟的中等强度或剧烈运动）的患者明显较少（32%）（p = 0.014）。患者的峰值耗氧量平均为23.5±6.3毫升·千克⁻¹·分钟⁻¹，而对照组为30.6±7.0毫升·千克⁻¹·分钟⁻¹（p<0.01）。与对照组相比，患者认知子领域的得分总体较低，尽管只有言语记忆方面的差异具有统计学意义（未校正p = 0.041）。在患者中，运动、峰值耗氧量与大多数认知子领域得分之间存在弱至中度的相关性；然而，运动与视觉记忆之间存在显著的正相关（r = 0.47，p = 0.004）。总之，完成原发性辅助化疗后的乳腺癌患者总体上比一般人群中的健康女性表现出更差的认知能力，且这种表现可能与其运动行为水平有关。
