Nilbert M, Heim S, Mandahl N, Flodérus U M, Willén H, Baldetorp B, Mitelman F
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Genes Chromosomes Cancer. 1989 Nov;1(2):131-4. doi: 10.1002/gcc.2870010204.
Cytogenetic investigation of short-term cultures from a bizarre leiomyoma of the uterus, a tumor type not hitherto karyotypically characterized, revealed two abnormal clones with multiple complex rearrangements. Three-fourths of the aberrant cells were hypodiploid with the composite karyotype 38-44,XX,-6,-7,-10, -11,+20,-22,r(1),der(2)(:2p23----cen----2q13::1q21---- 1qter),der(2)t(2; 9)(p21;q13),t(5;?)(q35;?), t(5;?),(q35;?),+der(5)t(5;15)(q11;q15), der(8)t(8;11)(q24;q13),t(15;?)(p12;?),der(16)t(12;16)(q13;p13),+r,+mar. The remaining abnormal mitoses were hypotetraploid, with chromosome numbers ranging from 74 to 86. These massively rearranged cells showed the same markers that were found in the hypodiploid clone, but in duplicate, indicating that this clone had arisen through polyploidization of hypodiploid cells. Flow cytometry revealed a DNA index of 1.03.
对一例子宫奇异平滑肌瘤（一种迄今尚未进行核型特征描述的肿瘤类型）的短期培养物进行细胞遗传学研究，发现了两个具有多个复杂重排的异常克隆。四分之三的异常细胞为亚二倍体，复合核型为38 - 44,XX,-6,-7,-10,-11,+20,-22,r(1),der(2)(:2p23----cen----2q13::1q21---- 1qter),der(2)t(2; 9)(p21;q13),t(5;?)(q35;?), t(5;?),(q35;?),+der(5)t(5;15)(q11;q15), der(8)t(8;11)(q24;q13),t(15;?)(p12;?),der(16)t(12;16)(q13;p13),+r,+mar。其余异常有丝分裂细胞为亚四倍体，染色体数在74至86之间。这些大量重排的细胞显示出与亚二倍体克隆中相同的标记，但为双倍体，表明该克隆是通过亚二倍体细胞的多倍体化产生的。流式细胞术显示DNA指数为1.03。
