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使用OX-19单克隆抗体对大鼠骨髓进行免疫磁性T淋巴细胞清除（ITLD）。

Immunomagnetic T-lymphocyte depletion (ITLD) of rat bone marrow using OX-19 monoclonal antibody.

作者信息

Hoffman A L, Makowka L, Cramer D V, Cai X, Pascualone A, Banner B F, Sheahan D G, Rettinger P, Starzl T E

机构信息

Department of Surgery, University of Pittsburgh School of Medicine, PA 15261.

出版信息

J Invest Surg. 1989;2(3):241-51. doi: 10.3109/08941938909057430.

DOI:10.3109/08941938909057430
PMID:2487253
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2975399/
Abstract

Graft versus host disease (GVHD) may be abrogated and host survival prolonged by in vitro depletion of T lymphocytes from bone marrow (BM) prior to allotransplantation. Using a mouse anti-rat pan T-lymphocyte monoclonal antibody (OX19) bound to monosized, magnetic, polymer beads, T lymphocytes were removed in vitro from normal bone marrow. The removal of the T lymphocytes was confirmed by flow cytometry. Injection of the T-lymphocyte-depleted bone marrow into fully allogeneic rats prevents the induction of GVHD and prolongs host survival.

摘要

移植物抗宿主病（GVHD）可通过在同种异体移植前体外去除骨髓（BM）中的T淋巴细胞来消除，并延长宿主存活时间。使用与单尺寸磁性聚合物珠结合的小鼠抗大鼠全T淋巴细胞单克隆抗体（OX19），在体外从正常骨髓中去除T淋巴细胞。通过流式细胞术确认T淋巴细胞的去除。将去除T淋巴细胞的骨髓注射到完全同种异体的大鼠中可防止GVHD的诱导并延长宿主存活时间。

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引用本文的文献

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Surgery. 1989 Aug;106(2):354-63.

本文引用的文献

1
Sequential morphology of graft-versus-host disease in the rat radiation chimera.大鼠辐射嵌合体中移植物抗宿主病的序贯形态学
Clin Immunol Immunopathol. 1982 Feb;22(2):203-24. doi: 10.1016/0090-1229(82)90038-1.
2
Effect of anti-T-cell globulin on GVHD in leukemic patients treated with BMT.
Transplant Proc. 1981 Mar;13(1 Pt 1):257-61.
3
The roles of host and donor cells in the rejection of skin allografts by T cell-deprived rats injected with syngeneic T cells.宿主细胞和供体细胞在注射同基因T细胞的T细胞缺失大鼠皮肤同种异体移植排斥反应中的作用。
Eur J Immunol. 1982 Jun;12(6):511-8. doi: 10.1002/eji.1830120612.
4
Cellular immunoabsorption using monoclonal antibodies. Selective removal of T cells from peripheral blood and bone marrow.使用单克隆抗体的细胞免疫吸附。从外周血和骨髓中选择性去除T细胞。
Transplantation. 1984 Aug;38(2):136-42.
5
Induction of Ia antigen in rat epidermal cells and gut epithelium by immunological stimuli.免疫刺激诱导大鼠表皮细胞和肠上皮细胞Ia抗原的产生。
J Exp Med. 1982 Dec 1;156(6):1665-76. doi: 10.1084/jem.156.6.1665.
6
Immunological mechanisms of graft-versus-host disease in man.人类移植物抗宿主病的免疫机制
Transplantation. 1982 May;33(5):459-64.
7
Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1).用单克隆大鼠抗人淋巴细胞抗体（CAMPATH-1）体外去除同种反应性淋巴细胞以消除移植物抗宿主病。
Lancet. 1984 Sep 1;2(8401):483-6. doi: 10.1016/s0140-6736(84)92564-9.
8
Ex-vivo treatment of donor bone marrow with anti-T-cell immunotoxins for prevention of graft-versus-host disease.用抗T细胞免疫毒素对供体骨髓进行体外处理以预防移植物抗宿主病。
Lancet. 1984 Mar 3;1(8375):469-72. doi: 10.1016/s0140-6736(84)92847-2.
9
Use of anti-T-cell monoclonal antibody OKT3 to prevent acute graft-versus-host disease in allogeneic bone-marrow transplantation for acute leukaemia.使用抗T细胞单克隆抗体OKT3预防急性白血病异基因骨髓移植中的急性移植物抗宿主病。
Lancet. 1982 Mar 27;1(8274):700-3. doi: 10.1016/s0140-6736(82)92619-8.
10
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