Muegge K, Durum S K
Biological Carcinogenesis Development Program, Program Resources, Inc., Frederick, MD.
New Biol. 1989 Dec;1(3):239-46.
Cytokines are polypeptides released by host cells during immune responses against foreign agents. Cytokines serve as intercellular messengers and induce transcription of a variety of genes in many different target cells. Transcriptional induction is mediated by transcription factors, which influence gene expression by interacting with specific elements in their regulatory regions. Here we discuss transcription factors involved in the regulation of cytokines and their receptors (interleukin-2, interleukin-2 receptor alpha chain, and interferon-beta), as well as transcription factors that are activated by cytokines (interleukin-1, tumor necrosis factor, interferons, and transforming growth factor beta).
细胞因子是宿主细胞在针对外来病原体的免疫反应过程中释放的多肽。细胞因子作为细胞间信使，可诱导许多不同靶细胞中多种基因的转录。转录诱导由转录因子介导，转录因子通过与调控区域中的特定元件相互作用来影响基因表达。在此，我们讨论参与细胞因子及其受体（白细胞介素-2、白细胞介素-2受体α链和干扰素-β）调控的转录因子，以及被细胞因子（白细胞介素-1、肿瘤坏死因子、干扰素和转化生长因子β）激活的转录因子。
