Calderón Jaimes E, Arredondo García J L, Olvera Salinas J, Echániz Aviles G, Conde González C, Hernández Nevárez P
Ginecol Obstet Mex. 1989 Apr;57:90-6.
A prospective study was carried out in which quantitative clean-voided urine cultures, were obtained at the first clinic visit from 986 consecutive pregnant women, followed to delivery to assess the maternal and pediatric finding associated with maternal asymptomatic bacteriuria. Patients to be evaluated were divided in two groups: Treatment group (TG) with 42/46 patients that were treated with nitrofurantoin 100 mg a day during 10 days, and control group (CG) with 45/46 patients that were not treated. Patients who failed were given a second course of nitrofurantoin. The patients who remained infected were given further treatment (cephalexin). Primary treatment was successful in 85%, 10% more with the second course and 5% were failure treatment. There was a highly significant difference in the incidence of symptomatic bacteriuria (pyelonephritis), premature deliver, prematurity and other perinatal events in patients with persistent infection. Eradication of asymptomatic bacteriuria reduced the risk of pre-term deliveries and lower infant birth weights for gestational age.
进行了一项前瞻性研究，在首次门诊就诊时，对986名连续的孕妇采集定量清洁中段尿培养物，随访至分娩，以评估与孕妇无症状菌尿相关的母体和儿科检查结果。待评估的患者分为两组：治疗组（TG），42/46例患者，每天服用100毫克呋喃妥因，持续10天；对照组（CG），45/46例患者，未接受治疗。治疗失败的患者接受第二个疗程的呋喃妥因治疗。仍有感染的患者接受进一步治疗（头孢氨苄）。初次治疗成功率为85%，第二个疗程后多10%，5%治疗失败。持续性感染患者的症状性菌尿（肾盂肾炎）、早产、早产和其他围产期事件的发生率存在高度显著差异。根除无症状菌尿可降低早产风险和小于胎龄儿的低出生体重风险。
