Wilson C, Cullen E, Sendell K
Department of Psychology, Lafayette College, Easton, PA 18042, U.S.A.
Int J Dev Neurosci. 1984;2(4):323-9. doi: 10.1016/0736-5748(84)90068-6.
In a series of six experiments, the ability of specific neurotransmitter antagonists to alter the 'transport response' was investigated in 19-day-old rat pups. The serotonergic blocker, methysergide, and the cholinergic blocker, scopolamine, did not produce any consistent changes in the intensity of the response. Likewise, the opiate receptor blocker, naloxone, was without effect. Large, dose-dependent decreases in transport response intensity were seen with administration of the beta-noradrenergic receptor blocker, propranolol, and with administration of the dopaminergic blocker, haloperidol. The alphanoradrenergic receptor blocker, phentolamine, produced inconsistent changes in the response. These results indicate a central catecholaminergic involvement in the transport response.
在一系列六项实验中，研究了特定神经递质拮抗剂改变19日龄幼鼠“转运反应”的能力。血清素能阻滞剂麦角酰二乙胺和胆碱能阻滞剂东莨菪碱并未使反应强度产生任何一致的变化。同样，阿片受体阻滞剂纳洛酮也没有效果。使用β-去甲肾上腺素能受体阻滞剂普萘洛尔和多巴胺能阻滞剂氟哌啶醇后，观察到转运反应强度出现了与剂量相关的大幅下降。α-肾上腺素能受体阻滞剂酚妥拉明使反应产生了不一致的变化。这些结果表明中枢儿茶酚胺能参与了转运反应。
