一种针对耐药病原体的前瞻性抗菌剂：一种双弹头两亲分子，旨在通过膜损伤和细胞DNA裂解来追踪相互作用并杀死病原菌。
A prospective antibacterial for drug-resistant pathogens: a dual warhead amphiphile designed to track interactions and kill pathogenic bacteria by membrane damage and cellular DNA cleavage.
作者信息
Thiyagarajan Durairaj, Goswami Sudeep, Kar Chirantan, Das Gopal, Ramesh Aiyagari
机构信息
Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati 781039, India.
出版信息
Chem Commun (Camb). 2014 Jul 18;50(56):7434-6. doi: 10.1039/c4cc02354d.
PMID:24874465
Abstract
A rationally designed bactericidal amphiphile acts on compelling targets and has the potential to disarm resistance development in pathogenic bacteria.
摘要
一种经过合理设计的杀菌两亲分子作用于具有说服力的靶点，并且有可能消除病原菌耐药性的产生。
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