Akgündüz Engin, Erkılınç Selçuk, Tokmak Aytekin, Güzel Ali İrfan, Özer İrfan, Danışman Nuri
Department of Obstetrics and Gynecology, Dr. Zekai Tahir Burak Women Health Education and Research Hospital , Ankara , Turkey.
J Matern Fetal Neonatal Med. 2015 Apr;28(6):722-5. doi: 10.3109/14767058.2014.929660. Epub 2014 Jun 25.
To evaluate placental thickness, Doppler velocimetry, biophysical profile and perinatal outcomes in pregnancies complicated by idiopathic polyhydramnios.
This prospective case-control study was conducted on 139 pregnant women, of these 70 patients with idiopathic polyhydramnios comprised the study group and 60 pregnant women comprised the control group. Risk factors recorded were; age, parity, body mass index (BMI), gestational weeks, amniotic fluid index (AFI), biophysical profiles (BPP), placental thickness, middle cerebral artery pulsatility index (MCA PI), umbilical artery Doppler velocimetry (Umb A S/D) values and perinatal outcomes.
Sixty-nine of the cases had mild-moderate (AFI: 250-450 mm) polyhydramnios (%98.5) and one of the cases had severe polyhydramnios (>450 mm) in study group. There was no statistically significant difference between the groups in terms of age, parity, BMI, gestational weeks, fetal birth weights and BPP (p > 0.05). Placental thickness, MCA PI and UA S/D values showed statistically significant difference between the groups (p < 0.05). The fetuses with lower placental thickness had lower scores of biophysical profile. There were negative correlations between placental thickness and AFI (r = -0.265), umbilical artery S/D and placental thickness (r = -0.212), MCA PI and AFI (r = -171, p = 0.44). However there was a positive correlation between AFI and umbilical artery Doppler values (r = 0.450).
Idiopathic polyhydramnios is associated with decreased placental thickness, impaired uterine, umbilical and middle cerebral artery flow.
评估特发性羊水过多妊娠中的胎盘厚度、多普勒血流测定、生物物理评分及围产期结局。
本前瞻性病例对照研究纳入了139名孕妇，其中70例特发性羊水过多患者组成研究组，60名孕妇组成对照组。记录的危险因素包括：年龄、产次、体重指数（BMI）、孕周、羊水指数（AFI）、生物物理评分（BPP）、胎盘厚度、大脑中动脉搏动指数（MCA PI）、脐动脉多普勒血流测定（脐动脉S/D）值及围产期结局。
研究组中69例为轻度至中度（AFI：250 - 450 mm）羊水过多（98.5%），1例为重度羊水过多（>450 mm）。两组在年龄、产次、BMI、孕周、胎儿出生体重及BPP方面无统计学显著差异（p > 0.05）。胎盘厚度、MCA PI及脐动脉S/D值在两组间存在统计学显著差异（p < 0.05）。胎盘厚度较低的胎儿生物物理评分较低。胎盘厚度与AFI（r = -0.265）、脐动脉S/D与胎盘厚度（r = -0.212）、MCA PI与AFI（r = -171，p = 0.44）之间存在负相关。然而，AFI与脐动脉多普勒值之间存在正相关（r = 0.450）。
特发性羊水过多与胎盘厚度降低、子宫、脐动脉及大脑中动脉血流受损有关。
