Vink Eva E, Goldschmeding Roel, Vink Aryan, Weggemans Callista, Bleijs Ronald L A W, Blankestijn Peter J
Department of Nephrology, University Medical Center Utrecht, Utrecht, Netherlands.
Department of Pathology, University Medical Center Utrecht, Utrecht, Netherlands.
Nephrol Dial Transplant. 2014 Aug;29(8):1608-10. doi: 10.1093/ndt/gfu192. Epub 2014 May 29.
Renal denervation (RDN) is a promising novel treatment for resistant hypertension. Effectiveness of treatment is, however, highly variable and unpredictable. Incomplete denervation of the renal nerves is a plausible explanation for the variable blood pressure lowering effect of RDN. Here, we present for the first time a histopathological evaluation of the effects of RDN on perivascular nerves of the renal arteries in a human patient. Our findings potentially have important implications for future directions with RDN.
肾去神经支配术（RDN）是一种有前景的顽固性高血压新型治疗方法。然而，治疗效果差异很大且不可预测。肾神经去神经支配不完全是RDN降压效果不一的一个合理原因。在此，我们首次展示了对一名人类患者肾动脉血管周围神经进行RDN治疗效果的组织病理学评估。我们的研究结果可能对RDN未来的发展方向具有重要意义。
