Kinashi T, Tashiro K, Inaba K, Takeda T, Palacios R, Honjo T
Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan.
Int Immunol. 1989;1(1):11-9. doi: 10.1093/intimm/1.1.11.
An interleukin-3-dependent progenitor clone LyD9 and its interleukin-4-dependent derivative clone K-4 were shown to differentiate into myeloid cells as well as B lymphocytes by coculture with bone marrow stroma cells. The K-4 clone is an intermediate between myeloid/lymphoid cells and the LyD9 clone that requires interleukin-4 for differentiation into B lymphocytes and myeloid cells. Granulocyte-macrophage colony stimulating factor-dependent derivatives (LS-1 and K-GM) were also established from induced LyD9 cells. LS-1 and K-GM were myeloid-committed cells.
一个白细胞介素-3依赖的祖细胞克隆LyD9及其白细胞介素-4依赖的衍生克隆K-4，通过与骨髓基质细胞共培养，被证明可分化为髓系细胞以及B淋巴细胞。K-4克隆是髓系/淋巴系细胞与LyD9克隆之间的中间体，LyD9克隆分化为B淋巴细胞和髓系细胞需要白细胞介素-4。粒细胞-巨噬细胞集落刺激因子依赖的衍生物（LS-1和K-GM）也从诱导的LyD9细胞中建立。LS-1和K-GM是髓系定向细胞。
