Ribatti Domenico
Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy; National Cancer Institute "Giovanni Paolo II", Bari, Italy.
Immunol Lett. 2014 Sep;161(1):96-9. doi: 10.1016/j.imlet.2014.05.010. Epub 2014 May 27.
Vertebrate make billions of different antibodies, each with a binding site that recognizes a specific region of a macromolecule. The hybridoma technique allows monoclonal antibodies, highly specific antibodies produced in the laboratory by a variety of methods. In the last 35 years since the first process for creating monoclonal antibodies was introduced, their application have improved the growing biotechnology industry, but the most important application concerns the therapy of human malignancies.
脊椎动物能产生数十亿种不同的抗体，每种抗体都有一个结合位点，可识别大分子的特定区域。杂交瘤技术能产生单克隆抗体，这是通过多种方法在实验室中制备的高度特异性抗体。自首个制备单克隆抗体的方法问世后的35年里，其应用推动了蓬勃发展的生物技术产业，但最重要的应用是在人类恶性肿瘤的治疗方面。
