胃泌素给药后大鼠胃中组胺的合成及胃酸分泌的阻断

Histamine synthesis after administration of gastrin and blockade of acid secretion in the rat stomach.

作者信息

Konagaya M, Harasawa S, Miwa T, Matsumoto M

机构信息

Department of Internal Medicine, School of Medicine, Tokai University, Kanagawa, Japan.

出版信息

Tokai J Exp Clin Med. 1989 Sep;14(4):309-14.

PMID:2487969

Abstract

Histidine decarboxylase (HDC) activity in the oxyntic gland and gastric volume were measured in rats treated with tetragastrin, cimetidine or omeprazole. HDC activity was dose dependently activated by not only tetragastrin but also cimetidine and omeprazole treatment. Histamine concentration in the oxyntic gland was reduced, but the amount of histamine in the gastric contents was increased by tetragastrin treatment. In rats premedicated with cimetidine or omeprazole, histamine concentration in the oxyntic gland and the amount of histamine in the gastric contents were not changed by administration of tetragastrin. It was concluded that tetragastrin activated HDC which increased histamine release into the gastric contents. Cimetidine and omeprazole induced the secretion of endogenous gastrin, leading to the activation of HDC.

摘要

在接受四肽胃泌素、西咪替丁或奥美拉唑治疗的大鼠中，测定了胃底腺中的组氨酸脱羧酶（HDC）活性和胃容积。HDC活性不仅被四肽胃泌素剂量依赖性激活，也被西咪替丁和奥美拉唑治疗激活。四肽胃泌素治疗使胃底腺中的组胺浓度降低，但胃内容物中的组胺量增加。在用西咪替丁或奥美拉唑预处理的大鼠中，给予四肽胃泌素后胃底腺中的组胺浓度和胃内容物中的组胺量未发生变化。得出的结论是，四肽胃泌素激活HDC，从而增加组胺向胃内容物中的释放。西咪替丁和奥美拉唑诱导内源性胃泌素的分泌，导致HDC的激活。